Mechanisms of inflammasome activation

Inflammasome activation and regulation: toward a better ... - Nature

The final common pathway of inflammasome signaling is inflammatory caspase-activation. This task is achieved by the assembly of a hetero- ...

Mechanisms of inflammasome activation: recent advances and ...

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading pathogens and other danger signals. Typically inflammasome complexes ...

Mechanisms of inflammasome activation and regulation | Journal of ...

In this review, we provide an overview of the cellular and molecular mechanisms involved in the regulation of inflammasome activation.

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β ...

The inflammasomes: mechanisms of activation and function - PMC

In response to injurious or infectious agents caspase-1 activating multiprotein complexes, termed inflammasomes, assemble in the cytoplasm of cells.

Recent advances in the mechanisms of NLRP3 inflammasome ...

It is well established that NLRP3 inflammasome activation triggers caspase-1 activation and IL-1β maturation through a two-step mechanism.

Mechanisms and Functions of Inflammasomes - Cell Press

Assembly of the canonical inflammasome complexes promotes the proximity-induced autoactivation of caspase-1. Caspase-1 subsequently converts its ...

A 360° view of the inflammasome: Mechanisms of activation, cell ...

Inflammasomes are critical initiators of inflammation and adaptive immunity with far-reaching effects on human health and disease. Inflammasome ...

The mechanism of NLRP3 inflammasome activation and its ...

The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.

Inflammasome activation: from molecular mechanisms to ...

Inflammasomes signalling pathways: NLRP1, NLRP3, NLRP 6 and 7, Pyrin, NAIP-NLRC4, AIM2, IFI16, COPs and POPs, Non-canonical inflammasome, Inflammasomes in

Mechanisms and Functions of Inflammasomes - ScienceDirect.com

Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering ...

Mechanisms of inflammasome activation: recent advances and ...

Inflammasomeactivationalsoresults in pyroptosis, an inflammatory form of cell death [2,3]. Inflammasomes are essential components of host defense and they guard ...

Mechanisms of Inflammasome Activation and Involvement in Liver ...

This review summarizes the mechanisms leading to inflammasome activation and the role it plays in hepatic physiology.

Mechanisms governing inflammasome activation, assembly and ...

Inflammasome sensors, in association with an adaptor protein—apoptosis-associated speck-like protein containing a caspase-activation and - ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ... - MDPI

The alternative NLRP3 inflammasome (right) is activated in human monocytes in response to LPS and requires receptor-interacting serine/threonine-protein kinase ...

Mechanism of NLRP3 inflammasome activation - Sutterwala - 2014

This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

Inflammasome Activation Pathways - R&D Systems

Inflammasome oligomerization leads to the activation of Caspase-1, followed by the maturation and secretion of IL-1 beta and IL-18, and in some cases, an ...

Mechanisms of inflammasome activation and regulation | Journal of ...

In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.

Inflammasome - Wikipedia

Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory responses and cell death.

Structural Mechanisms of NLRP3 Inflammasome Assembly and ...

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation ... Abstract. As an important sensor in the innate immune system, NLRP3 ...