Mechanisms of inflammasome activation and regulation

Mechanisms of inflammasome activation and regulation - PubMed

Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults.

Mechanisms of inflammasome activation and regulation | Journal of ...

In this review, we provide an overview of the cellular and molecular mechanisms involved in the regulation of inflammasome activation.

Inflammasome activation and regulation: toward a better ... - Nature

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an ...

The inflammasomes: mechanisms of activation and function - PMC

While defined ligands have been identified for the NLRP1, IPAF and AIM2 inflammasomes, little is known about the activation mechanisms of the NLRP3 inflammasome ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

In addition, NLRP3 inflammasome activation often leads to proinflammatory programmed cell death known as pyroptosis. The inflammasome complex ...

Mechanism and Regulation of NLRP3 Inflammasome Activation

The NLRP3 inflammasome is an essential mediator of host immune responses through the activation of caspase-1 and interleukin 1 beta (IL-1β)/IL-18.

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ... - MDPI

... mechanisms of NLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications and interacting partners of

Mechanisms of inflammasome activation and regulation | Journal of ...

In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.

Inflammasome activation: from molecular mechanisms to ...

Inflammasomes activate inflammatory caspases, which trigger a cascade of molecular events with the potential to compromise cellular integrity ...

Inflammasome activation by viral infection: mechanisms of ... - Frontiers

Inflammasomes play an important role in innate immunity and are crucial for the activation of inflammatory caspases and the subsequent ...

A 360° view of the inflammasome: Mechanisms of activation, cell ...

Several distinct proteins nucleate inflammasomes, including NLRP1, CARD8, NLRP3, NLRP6, NLRC4/NAIP, AIM2, pyrin, and caspases-4/-5/-11. This ...

Structural Mechanisms of NLRP3 Inflammasome Assembly and ...

As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds ...

Mechanisms of inflammasome activation: recent advances and ...

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading pathogens and other danger signals.

Structure, Activation and Regulation of NLRP3 and AIM2 ... - MDPI

... inflammasome components, their activation, interaction, mechanism of regulation, and finally, the formation of densely packed filamentous inflammasome ...

Mechanism and Regulation of NLRP3 Inflammasome Activation

The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1b) and IL-18 and the induction of ...

Mechanisms of inflammasome activation and regulation

An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The ...

Inflammasome and Autophagy Regulation: A Two-way Street

Inflammasome activation involves formation and oligomerization of a protein complex including a nucleotide oligomerization domain (NOD)-like ...

Inflammasome activation and regulation

Regulatory mechanisms of inflammasome activation. In general, in a well-timed and carefully controlled inflammatory response, it is critical to seek the ...

[PDF] The cell biology of inflammasomes - Semantic Scholar

The biological processes involved in the activation and regulation of the inflammasome, including secretion of cytokines, IL-1β and IL-18, and induction of ...