Mechanisms of tumor resistance to immune checkpoint blockade ...

Here, we focused on the changes in the biological functions of CD8 + T cells to elucidate the underlying resistance mechanisms of ICB therapies.

Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for various cancer types. Multiple single or combinations of ...

Mechanisms of Resistance to Immune Checkpoint Blockade

The tumor microenvironment, tumor immunogenicity, antigen presentation, and classic oncologic pathways play roles in response and resistance to immune ...

Mechanisms of tumor resistance to immune checkpoint blockade ...

Here, we focused on the changes in the biological functions of CD8 + T cells to elucidate the underlying resistance mechanisms of ICB therapies.

Mechanisms of resistance to immune checkpoint inhibitors - Nature

Importantly, alterations in genes encoding components of the antigen processing and/or presentation apparatus (e.g., class I MHC, β2- ...

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer

Here, we review how a range of cancer-cell-autonomous cues, tumor-microenvironmental factors, and host-related influences might account for the heterogeneous ...

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Evidence for key oncogenic processes that can potentially foster resistance to immunotherapy includes: (i) oncogenic cooperation, (ii) exclusion of CD8+ T cells ...

Mechanisms of drug resistance to immune checkpoint inhibitors in ...

In this review, we summarized the mechanisms of ICIs resistance in lung cancer and the factors which were associated with the clinical effects.

The molecular and functional landscape of resistance to immune ...

In this study, we comprehensively profile immune checkpoint inhibitor resistance mechanisms in short-term tumor cell lines and matched tumor samples from ...

Mechanisms of resistance to immune checkpoint inhibitors in ...

CAFs shape a dense fibrotic stroma which mechanistically blocks penetration of CTLs into the tumor tissue. Resistant melanoma cells experience an increase in ...

Full article: A landscape of checkpoint blockade resistance in cancer

Evidence indicates that mutations and epigenetic modifications in the cancer DNA that alter the antigen processing and presentation machinery can contribute to ...

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Immune checkpoint blockade inhibits T cell–negative costimulation in order to unleash antitumor T-cell responses that recognize tumor antigens. Importantly, the ...

Overcoming Resistance Mechanisms to Immune Checkpoint Inhibitors

Agents that disrupt a patient's normal gut microbiome, therefore, can contribute to resistance to ICIs. Concomitant medications including proton pump inhibitors ...

Acquired resistance for immune checkpoint inhibitors in cancer ...

The occurrence of acquired resistance following the use of ICIs can be summarized into the three following mechanisms: Mutation of tumor cells, upregulation of ...

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer

Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various ...

Immune Resistance Mechanisms and the Road to Personalized ...

For example, the interferon-gamma (IFNg)/janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling axis is one of the ...

Resistance Mechanisms to Anti-PD Cancer Immunotherapy

We review evidence for immune-based resistance mechanisms such as loss of neoantigens, defects in antigen presentation and interferon signaling, ...

Hallmarks of response, resistance, and toxicity to immune ...

Unprecedented advances have been made in cancer treatment with the use of immune checkpoint blockade. (ICB). However, responses are limited ...

Predictive Biomarkers and Resistance Mechanisms of Checkpoint ...

In conclusion, the interaction between checkpoint inhibitors and cancer cells is primarily focused on removing the inhibitory signals that prevent the immune ...

Mechanisms of Resistance to Immune Checkpoint Blockade

Future directions in ICI are outlined, including the development of new therapeutic targets, rational combination therapies, integrated predictive models ...