Metabolic pathway analysis using stable isotopes in patients with ...

Stable-isotope tracing is an informative, versatile method for probing tumour metabolism in vivo. It has been used extensively in preclinical ...

Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the relative rates of reprogrammed ...

Stable Isotope Tracing Analysis in Cancer Research - PubMed Central

Stable isotope tracing has emerged as a widely adopted tool for monitoring cancer metabolism both in vitro and in vivo. Advances in instrumentation and the ...

[Article] Metabolic pathway analysis using stable isotopes in patients ...

[Article] Metabolic pathway analysis using stable isotopes in patients with cancer by Caroline R. Bartman, Brandon Faubert, Joshua D. Rabinowitz ...

Metabolic pathway analysis using stable isotopes in patients ... - OUCI

Schoenheimer, R. & Rittenberg, D. Deuterium as an indicator in the study of intermediary metabolism. Science 82, 156–157 (1935). This paper reports the first ...

Exploring cancer metabolism using stable isotope-resolved ...

Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms ...

Stable isotope-labeling studies in metabolomics

Alternatively, for detailed analysis of central carbon metabolism it may be more appropriate to use 13C-1,2-glucose to allow delineation of metabolites arising ...

Applications of Stable Isotope Labeling in Metabolic Flux Analysis

A common use case is the discovery of new metabolic pathways, a task achievable through a careful analysis of the isotopic labeling patterns in metabolites.

Isotope tracing in health and disease - ScienceDirect.com

This advanced analysis of isotope tracing data yields comprehensive quantitation of fluxes for all metabolic pathways of interest. In this ...

Untargeted stable isotope-resolved metabolomics to assess the ...

... metabolic flux analysis. In this ... Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry.

Global stable-isotope tracing metabolomics reveals system-wide ...

Stable-isotope tracing metabolomics allows to unravel metabolic activity quantitatively by measuring the isotopically labeled metabolites, but ...

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic ...

Stable isotopes are becoming more commonly used in untargeted metabolomics studies to facilitate the quantification and identification of ...

Stable Isotope Tracing Metabolomics to Investigate the Metabolic ...

Conventional metabolomics experiments are done by analyzing metabolite abundances. This has very limited implications in studying pathway activity. The ...

Stable Isotopes - Sigma-Aldrich

The use of our stable isotope-labeled compounds in metabolic and nutritional studies provides a means to dissect biochemical pathways. The availability of ...

Stable Isotope Tracers for Metabolic Pathway Analysis - ResearchGate

Stable isotope tracing allows a metabolic substrate to be followed through downstream biochemical reactions, thereby providing unparalleled insights into ...

13C-Stable isotope resolved metabolomics uncovers dynamic ...

Stable isotope resolved metabolomics (SIRM) enables the dynamic tracking of individual atoms through metabolic networks [7]. Our group ...

The marriage between stable isotope ecology and plant ...

In plant metabolomics, label-free metabolic pathway and metabolic flux analysis might become possible when applying this new technology.

Radioactive and stable isotopes of metabolic pathway.

A clear utilization of isotopic tracers is to test whether a given pathway exists and how dynamic it is, for instance, by estimating the collection of isotopic ...

Comprehensive stable-isotope tracing of glucose and amino acids ...

Advanced mass spectrometry tools were applied to identify metabolic by-products and their sources. Specific by-products inhibited cell growth ...

Exploring cancer metabolism using stable isotope-resolved ...

This review focuses on the applications of stable isotope-resolved metabolomics to cancer metabolism and its use in understanding drug actions.