Metabolic preconditioning in CD4 T cells restores inducible ...

Metabolic preconditioning in CD4+ T cells restores inducible ...

Autoimmune disease has presented an insurmountable barrier to restoration of durable immune tolerance. Previous studies indicate that ...

Metabolic preconditioning in CD4 + T cells restores inducible ...

Our results demonstrate that metabolism is a fundamental target of tolerance-inducing therapy and, hence, changes in the metabolic condition of ...

Metabolic preconditioning in CD4+ T cells restores inducible ...

Our results demonstrate that metabolism is a fundamental target of tolerance-inducing therapy and, hence, changes in the metabolic condition of T cell targets ...

(PDF) Metabolic pre-conditioning in CD4 T cells restores inducible ...

In an animal model of lupus, we determined that targeting glucose metabolism with 2-deoxyglucose (2DG) and mitochondrial metabolism with metformin enables ...

Metabolic preconditioning in CD4+ T cells restores ... - JCI Insight

Metabolic preconditioning in CD4 T cells restores inducible immune tolerance in lupus-prone mice ... Citation Information: JCI Insight. 2021;6(19) ...

Metabolic preconditioning in CD4+ T cells restores inducible ...

Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice. JCI insight (2021-08-18). Christopher S Wilson, Blair T ...

Metabolic reinvigoration of immune tolerance - Nature

The altered metabolism in CD4+ T cells from lupus-prone mice led to reduced cell surface levels of CD45RB, the target of the therapeutic ...

Cellular metabolism regulates the differentiation and function of T ...

Upon T-cell receptor (TCR) activation and exposure to lineage-specific cytokines, naïve CD4 + T cells undergo differentiation into various ...

Metabolic reprogramming orchestrates CD4+ T-cell immunological ...

Original article. Metabolic reprogramming orchestrates CD4+ T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated ...

Canagliflozin impairs T cell effector function via metabolic ...

Here, cana was able to suppress total CD4+ T cell counts and a reducing trend in IFNγ production, but at higher concentrations than those when ...

Cell metabolism-based optimization strategy of CAR-T cell function ...

Naïve T cells(Tn)remain in a quiescent state, with low metabolic demands, and use predominantly mitochondrial oxidative phosphorylation (OXPHOS) fueled by small ...

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α ...

The inhibitory effects of cancer on T cell metabolism have been well established, but the metabolic impact of immunotherapy on tumor cells ...

Canagliflozin impairs T cell effector function via metabolic ...

Metabolic preconditioning in CD4+. T cells restores inducible immune tolerance in lupus-prone mice. ... Naıve (Tnv) and effector (Teff) CD4+ T ...

Effector CD4 T cells from lupus-prone mice resist CD4Treg-mediated...

These findings indicate that metabolic therapy may be applied as a powerful preconditioning to reinvigorate tolerance mechanisms in autoimmune and transplant ...

PPARβ/δ-orchestrated metabolic reprogramming supports the ...

Naïve CD8+ T cells up-regulate the mammalian target of rapamycin (mTOR) pathway and aerobic glycolysis after proper activation of their T cell ...

Fundamentals of T Cell Metabolism and Strategies to Enhance ...

Thus, glycolysis regulates effector T cell functionality; while CD4+ T cells moonlight GAPDH to regulate cytokine translation, both CD4+ and CD8+ T cells use ...

Metabolic Preconditioning Improves Engineered T Cell Fitness and ...

Metabolism has a strong influence on. T cell fate and potency.10 Furthermore, characterizing the metabolic profile of. CAR/TCR T cells for clinical cell ...

Circulation of gut-preactivated naïve CD8+ T cells enhances ... - PNAS

Microbial dysbiosis in these BCD mice enriched the type I IFN (IFN) signature in mucosal CD8+ T cells, resulting in up-regulation of the type I IFN-inducible ...

CD45R (B220) Antibody PE-Cyanine5 from Thermo Fisher Scientific

(9) Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone miceJCI insightOctober 8, 2021Wilson CS, Stocks BT, Hoopes ...

Regulation of T-cell tolerance by calcium/NFAT signaling. - Abstract

... Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice. Wilson CS, Stocks BT, Hoopes EM, Rhoads JP, McNew KL ...