Metabolic reprogramming and dysregulated IL|17 production ...

Metabolic reprogramming and dysregulated IL-17 production ...

Here we showed that sepsis induced chronic increased and non-specific production of IL-17 by CD4 T cells, resulting in the inability to mount an effective ...

Metabolic reprogramming and dysregulated IL-17 production ...

Our findings reveal cell metabolism as a potential therapeutic target. Given the critical role of cell metabolism in the physiological and ...

Metabolic reprogramming and dysregulated IL-17 ... - NASA ADS

NASA/ADS · Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis.

Metabolic reprogramming and dysregulated metabolism

Straus D.S. (2013) TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol. Cancer, 12 ...

IL-17A produced by POMC neurons regulates diet-induced obesity

... dysregulation can lead to obesity and metabolic disorders. Here we ... IL-17A is known to promote obesity through metabolic reprogramming of adipocytes,.

Metabolic reprogramming and dysregulated IL-17 production ... - OUCI

Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis. https://doi.org/10.1016/j.isci.2024.110114 ·. Journal ...

The Alterations in and the Role of the Th17/Treg Balance ... - Frontiers

Metabolic reprogramming is necessary during T-cell activation. Th17 cells, as effector T cells of the short-lived inflammatory T cell population, are ...

The metabolism-modulating activity of IL-17 signaling in health and ...

... IL-17–mediated metabolic-immune regulation in adipose tissue? One could speculate that the increase in IL-17 production observed in metabolic ...

IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated ...

... IL-17A in the metabolic reprogramming of human primary keratinocytes (HPKs). High-throughput liquid chromatography–tandem mass spectrometry ...

Immunometabolic Regulation of Interleukin-17-Producing T Helper ...

hypothesized its importance in regulating the cellular metabolic reprogramming of Th17 cells (34). ... dysregulated T cell metabolism by systemically changing ...

Metabolic regulation of the immune system in health and diseases

Serine metabolism supports macrophage IL-1β production. Cell ... Metabolic reprogramming is required for antibody production that is ...

The cancer metabolic reprogramming and immune response

Actually, lactate produced by tumor cells might contribute to tumorigenesis by promoting IL-23-mediated and IL-17-mediated inflammation [63]. In ...

Metabolic reprogramming in inflammaging and aging in T cells

Of note, aged T cells upregulate the production of several proinflammatory cytokines, including tumor necrosis factor (TNF), IL-6, and osteopontin, which ...

Precision nutrition to reset virus-induced human metabolic ... - Nature

... metabolic 'dysregulation' in the body. Interaction of SARS-CoV-2 proteins with specific host cell targets also rewire metabolic ...

Dysregulated metabolic enzymes and metabolic reprogramming in ...

As the majority of cancer cells are dependent on aerobic glycolysis for ATP production, the enzyme, lactate dehydrogenase (LDH), which catalyzes ...

Metabolic pathways in T cell activation and lineage differentiation

... Th17, orchestrate immunity against pathogens, while they can cause immunopathology upon dysregulation. ... IL-17-production. These defects were associated with ...

Metabolic reprogramming consequences of sepsis: adaptations and ...

Similarly in LPS-stimulated BMDMs, metformin, without AMPK activation, decreased LPS-induced production of the pro-IL-1β at both the mRNA and ...

Metabolic reprogramming in cancer: Mechanisms and therapeutics

... metabolic reprogramming and regulate fatty acid metabolic enzymes to regulate fatty acid production in lung cancer cells. The KRAS ...

Metabolic reprogramming in macrophage responses

... production of IL-1β, fueling tissue inflammation (Fig. 1VI) [55] ... Immune-responsive gene 1 protein links metabolism to immunity by catalyzing ...

Host metabolic reprogramming in response to SARS-CoV-2 infection

Our analysis revealed the host-dependent dysregulation of glycolysis, mitochondrial metabolism, amino acid metabolism, nucleotide metabolism, glutathione ...