Metabolic reprogramming in inflammaging and aging in T cells

Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging.

Age-associated remodeling of T cell immunity and metabolism - PMC

Age-associated mitochondrial and metabolic reprogramming has a direct impact on the immune system and its role in diseases such as cancer, autoimmunity and ...

Review Age-associated remodeling of T cell immunity and metabolism

Age-associated mitochondrial and metabolic reprogramming has a direct impact on the immune system and its role in diseases such as cancer, ...

Metabolic pathways in immune senescence and inflammaging ...

Accumulation of senescent cells, both age-dependent and due to inflammaging, are a common pathogenic hallmark of chronic non-communicable ...

Immunometabolism at the cornerstone of inflammaging ... - Aging-US

The metabolism drives immune T-cell activation and differentiation [10, 11, 72]. Cytokines, metabolic substrates, epigenetic reprogramming and ...

OP0312 METABOLIC REPROGRAMMING IN MEMORY CD4+ T ...

Conclusion: These findings suggest that metabolic reprogramming in human memory CD4+ T cells during aging results in an increased expression of proinflammatory ...

Metabolic programs tailor T cell immunity in viral infection, cancer ...

Cellular metabolic reprogramming could induce T cell functional deficits in healthy aging cells, or during infection and cancer (Quinn et al ...

Metabolic reprogramming and dysregulated IL-17 production ...

Higher frequency of cells with dysfunctional mitochondria was present in post-septic CD4 T cells (d21 and up to 9-week) compared to non-septic control cells or ...

T-Cell Senescence in Human Metabolic Diseases

The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic ...

Cellular senescence and metabolic reprogramming: Unraveling the ...

T cells, a major component of the human immune system, serve as crucial immunological mediators against infection and tumor development by ...

Targeting Aging: Lessons Learned From Immunometabolism and ...

Metabolic alterations are closely linked to the changes seen in various immune cell populations, including T cells, with aging. This can result ...

Age-associated remodeling of T cell immunity and metabolism

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes in age-related diseases such as cancer.

Metabolic Reprogramming in Memory CD4+ T Cells Is Associated ...

Conclusion: These findings suggest that metabolic reprogramming in human memory CD4+ T cells during aging results in an increased expression of proinflammatory ...

Inflammation, epigenetics, and metabolism converge to cell ... - Nature

Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that ...

T-Cell Metabolic Reprogramming in Atherosclerosis - MDPI

Lipid metabolic reprogramming is crucial for the activation, proliferation, and growth of anti-inflammatory T-cells. The metabolic flexibility of Th2 cells and ...

Advances in reprogramming of energy metabolism in tumor T cells

Following activation, T cells may undergo metabolic reprogramming characterized by a switch from oxidative metabolism to aerobic glycolysis, also known as ...

Connecting aging biology and inflammation in the omics era - JCI

Via the SASP, senescent cells contribute to multiple chronic health conditions associated with inflammaging, e.g., atherosclerosis (16), ...

Therefore, we hypothesized that metabolic reprogramming of CD4+ T cells may be a major factor promoting immune cell dysfunction during aging, contributing to ...

Metabolic Reprogramming in Immune Response and Tissue ...

In general, upon activation, immune cells switch from OXPHOS to glycolysis for quick ATP production. In the memory stage, innate immune cell ...

The metabolic roots of senescence: mechanisms and opportunities ...

Cellular senescence entails a permanent proliferative ... In all cases, senescent cells must undergo metabolic reprogramming in order to ...