Metabolic reprogramming of macrophages in the context of type 2 ...

This review aims to clarify the contribution of macrophages to the progression of T2D by detailing how their inflammatory responses and metabolic reprogramming ...

Last updated: Wed, 16 Oct 2024 13:32:43 Z. Metabolic reprogramming of macrophages in the context of type 2 diabetes. European Journal of Medical Research. ISSN ...

(PDF) Metabolic reprogramming of macrophages in the context of ...

Type 2 diabetes (T2D) is associated with insulin resistance and progressive dysfunction of β-pancreatic cells, leading to persistent ...

Meta-Inflammation and Metabolic Reprogramming of Macrophages ...

Diabetes mellitus type II and obesity are two important causes of death in modern society. They are characterized by low-grade chronic ...

Metabolic flux in macrophages in obesity and type-2 diabetes

The inflammatory responses of macrophages are supported by different metabolic pathways (glycolysis, glucose oxidation, fatty acid oxidation, ...

Metabolomic analysis reveals macrophage metabolic ...

In this study, we employed metabolomic approaches to examine the metabolic responses of macrophages to high glucose, high fat and their ...

Metabolic reprogramming of macrophages in the context of type 2 ...

In T2D, pro-inflammatory macrophages, which rely on glycolysis, exacerbate insulin resistance through increased production of pro-inflammatory ...

Metabolic reprogramming in macrophages and dendritic cells in ...

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis ...

Macrophage Polarization, Metabolic Reprogramming, and ...

This phenomenon is marked by alterations in multiple metabolic pathways: 1) glycolysis, 2) OXPHOS, 3) TCA cycle, and 4) fatty acid oxidation ( ...

Macrophage Polarization in Obesity and Type 2 Diabetes

Epigenetic mechanisms of macrophage activation in type 2 diabetes. · Metabolic reprogramming of macrophages in the context of type 2 diabetes · Adipose tissue ...

Metabolic programming of macrophage functions and pathogens ...

Pyruvate kinase M2 (PKM2, catalyzes final step of glycolysis) has been implicated in the promotion of inflammasome activation for IL-1β release [45], and 2- ...

Metabolism of tissue macrophages in homeostasis and pathology

This context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their ...

Metabolic programming of tumor associated macrophages in the ...

Macrophages are abundant immune cells in the TME of most tumors and their presence is thought to be associated with tumor progression and poor ...

Metabolic influence on macrophage polarization and pathogenesis

These findings imply that metabolic adaption to their surrounding microenvironment instructs activation of macrophages with functionally distinct phenotypes, ...

Metabolic Regulation of Adipose Tissue Macrophage Function in ...

Metabolic reprogramming of macrophages in the context of type 2 diabetes · Medicine, Biology. European journal of medical research · 2024.

The Metabolic Signature of Macrophage Responses - Frontiers

In particular, M1 macrophages rely mainly on glycolysis and present two breaks on the TCA cycle that result in accumulation of itaconate (a microbicide compound) ...

Metabolic Regulation of Macrophage Activation - Karger Publishers

In the context of diseases, systemic changes also affect macrophage metabolism, as in diabetes and insulin resistance, which results in altered ...

Metabolic regulation of macrophages during tissue repair: insights ...

A major player in skeletal muscle regeneration is the satellite cell, which was shown to be the main adult muscle stem cell responsible for ...

Immunometabolism governs dendritic cell and macrophage function

Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but ...

Metabolic reprogramming of macrophages in the context of type 2 ...

These innate immune cells respond to inflammatory stimuli and reprogram their metabolism, directly impacting the pathophysiology of T2D. Macrophages are highly ...