Metabolism|regulated ferroptosis in cancer progression and therapy

Metabolism-regulated ferroptosis in cancer progression and therapy

Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed.

Ferroptosis in cancer: from molecular mechanisms to therapeutic ...

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides.

Ferroptosis in cancer therapy: a novel approach to reversing drug ...

found that the therapy-resistant high-mesenchymal cell state depends on the GPX4-regulated lipid-peroxidase pathway that protects against ...

Targeting ferroptosis for cancer therapy: iron metabolism and ...

During the development and progression of cancer, the metabolism within cancer cells undergoes subtle changes. Cancer cells undergo stronger oxidative ...

Metabolic regulation of ferroptosis in the tumor microenvironment

Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by impaired redox and antioxidant machinery and propagated by the ...

Ferroptosis in Cancer Progression - MDPI

Ferroptosis is a newly discovered iron-dependent form of regulated cell death driven by phospholipid peroxidation and associated with processes including ...

Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy

Ferroptosis refers to iron-dependent, specialized, and regulated-necrosis mediated by lipid peroxidation, which is closely related to a variety of diseases, ...

Targeting ferroptosis for cancer therapy: exploring novel strategies ...

Ferroptosis roles as a double-edged sword either suppressing or promoting tumor progression with the release of multiple signaling molecules in the tumor ...

The roles of ferroptosis in cancer: Tumor suppression ... - Cell Press

Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has emerged as one ...

The epigenetic regulators and metabolic changes in ferroptosis ...

However, to some extent, ferroptosis is a type of autophagy-dependent cell death (ADCD) in some cancer cells, resulting from tumor heterogeneity ...

Cholesterol-ferroptosis nexus: Unveiling novel cancer therapeutic ...

Ferroptosis, a novel form of regulated cell death characterized by iron-mediated lipid peroxidation, holds immense potential in cancer ...

The roles of ferroptosis in cancer: Tumor suppression ... - Cell Press

Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has ...

Ferroptosis and EMT: key targets for combating cancer progression ...

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial steps in the formation of ferroptosis include ...

Molecular mechanisms of ferroptosis and its role in cancer therapy

Multiple signalling pathways as well as the cell organelles have also been found to involve in the ferroptosis regulation. Moreover, a series of ...

Ferroptosis-mediated Crosstalk in the Tumor Microenvironment ...

Emerging evidence has shown that ferroptosis is closely related to cancer progression and therapy. The triggers of ferroptosis, including iron accumulation, ...

Redox-Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer

Ferroptosis, as a novel treatment for ovarian cancer, remains in the experimental stages, confined to cell line and animal model studies, and has not yet ...

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis ...

The continued advancement and refinement of GPX4 inhibitors will enrich the repertoire of tools available for exploring ferroptosis induction as a therapeutic ...

Ferroptosis in Cancer Therapy | DDDT - Dove Medical Press

There is a growing body of evidence indicating that ferroptosis plays a critical role in the advancement of tumors. The increased metabolic ...

Exploring Ferroptosis-Inducing Therapies for Cancer Treatment

Ferroptosis—an iron-dependent regulated cell death triggered by lipid peroxide accumulation—has gained prominence in cancer research in recent ...

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Ferroptosis is regulated by specific signal transduction pathways through iron accumulation, lipid peroxidation and cellular membrane destruction, and ...