Metabolism in pluripotency

Metabolism in pluripotency: Both driver and passenger? - PMC

Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic demands to power rapid division. For many years considered a ...

Energy Metabolism Regulates Stem Cell Pluripotency - Frontiers

This review highlights the roles of the major metabolic pathways in the acquisition and maintenance of the different states of pluripotency.

Metabolism in pluripotency: Both driver and passenger? - PubMed

Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic demands to power rapid division.

Metabolism of human pluripotent stem cells and differentiated cells ...

This review details the current metabolic understanding of hPSCs and their derivatives, and compares them to mouse PSCs (mPSCs) and cancer cells.

Metabolic regulation in pluripotent stem cells - ScienceDirect.com

PSCs reshape their metabolic profile during developmental progression. Fatty acid oxidation is strictly required for energy production in naive PSCs.

Pluripotent stem cell energy metabolism: an update - EMBO Press

Abstract. Recent studies link changes in energy metabolism with the fate of pluripotent stem cells (PSCs). Safe use of PSC derivatives in regenerative medicine ...

Metabolism in Pluripotent Stem Cells and Early Mammalian ...

MYC and mTOR are required for anabolic metabolism in mouse ESCs and embryos, with loss of mTOR and MYC generating a dormant state that resembles ...

Metabolic control of induced pluripotency - Frontiers

In this review, we discuss the achievements in the current understanding of the molecular mechanisms of processes controlled by metabolic pathways.

Metabolism in pluripotency: Both driver and passenger?

This review provides an update and analysis of our current understanding of PSC metabolism and its role in self-renewal, differentiation, and somatic cell ...

Metabolic remodeling during the loss and acquisition of pluripotency

3A). Metabolic reprogramming encompasses not only morphological changes in mitochondria, but also their functional role (Fig. 3B). Most ...

Metabolism in Pluripotent Stem Cells and Early Mammalian ...

Core pluripotency factors and developmental regulators reciprocally control the expression of key metabolism genes and their encoded pathways.

Perspective Metabolic Regulation in Pluripotent Stem Cells during ...

Here, we discuss the emerging roles for metabolism in PSC self-renewal, differentiation, and reprogramming.

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell ...

Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome. However, induced pluripotent stem cells ...

Energy Metabolism in Human Pluripotent Stem Cells and ... - PLOS

ATP levels, lactate production and OCR revealed that human pluripotent cells rely mostly on glycolysis to meet their energy demands.

Cellular metabolism and homeostasis in pluripotency regulation

Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation.

Glutamine independence is a selectable feature of pluripotent stem ...

Given the emerging links between proliferative metabolism and cell identity, we speculated that we could exploit the specific metabolic ...

The metabolome of induced pluripotent stem cells reveals metabolic ...

Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells (iPSCs) remains largely ...

Both driver and passenger? - ETSU Libraries - Ex Libris Discovery

Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic demands to power rapid division. For many years considered a ...

Metabolism in Pluripotent Stem Cells and Early Mammalian ...

Core pluripotency factors and developmental regulators reciprocally control the expression of key metabolism genes and their encoded pathways. Recent ...

Energy Metabolism Regulates Stem Cell Pluripotency - Mayo Clinic

Abstract. Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited self-renewal and their potential to ...