Methionine Metabolism Shapes T Helper Cell Responses through ...

Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery.

Effect of methionine-restricted diet on T cell responses in vivo. Page 3. Figure S1, Related to Figure 1. Activated CD4+ T cells display increased methionine.

Methionine Metabolism Shapes T Helper Cell Responses through ...

Our data identify methionine as a key nutritional factor shaping Th cell proliferation and function in part through regulation of histone methylation.

Methionine Metabolism Shapes T Helper Cell Responses through ...

Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that ...

Methionine Metabolism Shapes T Helper Cell Responses through ...

Request PDF | Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming | Epigenetic modifications on DNA and ...

GSE143322 - GEO Accession viewer

Title, Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming ; Summary, This SuperSeries is ...

Methionine Metabolism Shapes T Helper Cell Responses through ...

. Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. ; Roy, Dominic G. ; Chen, Jocelyn ; Mamane, ...

Methionine cycle-dependent regulation of T cells in cancer immunity

The anti-tumor function of T cells is closely related to the metabolism of amino acids and other nutrients in T cells (1, 2). For example, ...

Methionine consumption by cancer cells drives a progressive ...

Reduced methionine increases PD-1 expression on CD4 T cells. The genetic ablation of SLC43A2 in cancer cells restores methionine metabolism in ...

A Tug-of-War Over Methionine - ScienceDirect

Amino acid uptake is also elevated in activated T cells, with the essential amino acid methionine being of special interest. Notably, as a ...

Antigen receptor control of methionine metabolism in T cells - eLife

Only T cells that respond to antigen to upregulate and sustain methionine transport are supplied with methyl donors that permit the dynamic ...

A mitochondrial STAT3-methionine metabolism axis promotes ILC2 ...

Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming. Cell Metab. 2020; 31:250-266. Full Text.

Tumor methionine metabolism drives T-cell exhaustion in ... - Nature

Our results reveal the central role of tumor methionine recycling pathway as a driver of T-cell dysfunction in HCC, leading tumor immune evasion.

Methionine - Metabolite - biocrates life science ag

et al.: Methionine metabolism shapes t helper cell responses through regulation of epigenetic reprogramming. (2020). Cell Metab | DOI ...

T Cell Activation: The importance of methionine metabolism - eLife

T helper cells import methionine to synthesize new proteins and to provide the methyl groups needed for the methylation of RNA and DNA that drives T cell ...

A novel methionine metabolism-related signature predicts prognosis ...

Interestingly, two recent studies have also identified a causal link between tumor methionine metabolism and T cell immunity in the tumor ...

š! Cancer cells steal methionine and impair CD8 Tâ

Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming. Cell Metab 2020;. 31: 250–266.e9. 9. Sinclair LV, Howden ...

Methionine deficiency facilitates antitumour immunity by ... - Gut

Mechanistically, the S-adenosylmethionine derived from methionine metabolism promoted the N6-methyladenosine (m6A) methylation and translation of immune ...

Metabolism along the life journey of T cells - Oxford Academic

The roles of common metabolic pathways, including glycolysis, lipid metabolism, and mitochondrial oxidative phosphorylation, in T-cell responses have been well ...

Nutrients: Signal 4 in T cell immunity - Rockefeller University Press

T cell activation requires the uptake of certain extracellular nutrients and coordination of intracellular metabolism, which enables cells to ...