MicroRNA|34 family

MicroRNA-34 family: a potential tumor suppressor and therapeutic ...

MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of ...

The miR-34 family in cancer and apoptosis - Nature

Recently, the transcription factor encoded by tumor suppressor gene p53 was shown to regulate the expression of microRNAs.

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic ...

As a tumor suppressor gene, miR-34 exerts important regulatory functions in GC by inducing apoptosis, cell senescence, and cell cycle arrest, thereby inhibiting ...

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic ...

MicroRNA (miRNA) are small noncoding RNAs that play vital roles in post-transcriptional gene regulation by inhibiting mRNA translation or ...

microRNA-34 family: From mechanism to potential applications

miR-34 family is a multifunctional miRNA family identified to be pivotal in organ development, organismal or organ senescence, stress response, spermatogenesis ...

mir-34 microRNA precursor family - Wikipedia

mir-34 microRNA precursor family ... The miR-34 microRNA precursor family are non-coding RNA molecules that, in mammals, give rise to three major mature miRNAs.

Distinct roles of miR-34 family members on suppression of lung ...

Highlights. •. Both miR-34a and miR-34b/c was decreased in occupational-exposure-related lung squamous cell carcinoma patients. •. miR-34b/c works more than miR ...

Neurodevelopment regulators miR-137 and miR-34 family as ...

We aimed to identify a set of aberrant neurodevelopmental-related miRNAs that could serve as potential biomarkers for EOS or schizophrenia with NSS.

MicroRNA-34 family in breast cancer: from research to therapeutic ...

MicroRNA (miRNA)-34 family (miR-34s), including miR-34a/b/c, is the most well studied non-coding RNAs that regulate gene expression post-transcriptionally. The ...

The miR-34 family and its clinical significance in ovarian cancer

Our findings suggest that downregulation of miR-34 family is a crucial part in ovarian cancer development. Low miR-34 levels are linked to a worse overall ...

The MicroRNA Family Gets Wider: The IsomiRs Classification and ...

In this review, we summarize the distinct classes of isomiRs, their regulation and biogenesis, and the active role of these newly discovered molecules in ...

The microRNA-34 Family and Its Functional Role in Lung Cancer

The miR-34 family is downregulated in lung cancer. It inhibits cell proliferation, metastasis, and invasion, arrests the cell cycle, and induces apoptosis or ...

miR-34: from bench to bedside - Oncotarget

Ectopic expression of the members of the miR-34 family can recapitulate some biological functions of p53 such as apoptosis [20, 50] and cell ...

MicroRNA-34 family expression in bovine gametes and ...

Recent evidence demonstrates that the miR-34 family of miRNA are involved in both spermatogenesis and early events of embryogenesis.

Molecular Evolution of a Primate-Specific microRNA Family

We report evidence of an Alu-mediated rapid expansion of miRNA genes in a previously identified primate-specific miRNA family.

Suppression of non-small cell lung tumor development by the let-7 ...

Furthermore, recent studies have shown that p53 transcriptional activation targets the miR-34 family in a step important for cell cycle control (13–15). In ...

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic ...

The design of miR-34 mimics tailored for cancer cells and their delivery systems can minimize off-target effects and improve specificity. The ...

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic ...

Among the tumor-suppressive miRNAs, the miR-34 family (miR-34s) has emerged as a prominent player in various human diseases, particularly cancer ...

Abstract 4162: MicroRNA-34 family is increased in human colon ...

Abstract. Purpose: The microRNA-34 family (miR-34a, -34b and -34c) have been reported to be tumor suppressor microRNAs (miRNAs) that are ...

Mir-34: A New Weapon Against Cancer? - Cell Press

miR-34 family, thus, contributes to p53 downstream effects on proliferation arrest and induction of apoptosis, by targeting c-MYC, CDK6, and c-MET. 30.