Micronuclei|based model system reveals functional consequences ...

Micronuclei-based model system reveals functional consequences ...

We show that human cells with extra chromosome engineered via microcell-mediated chromosome transfer often gain massive chromosomal rearrangements.

Micronuclei-based model system reveals functional consequences ...

The chromosomal rearrangements in trisomic cells provide growth advantage compared to cells without rearrangements. Our model system enables to ...

Micronuclei-based model system reveals functional consequences ...

We show that human cells with extra chromosome engineered via microcell-mediated chromosome transfer often gain massive chromosomal rearrangements.

Micronuclei-based model system reveals functional consequences ...

The rearrangements arose by chromosome shattering and rejoining as well as by replication-dependent mechanisms. We show that the isolated micronuclei lack ...

the causes and consequences of micronucleus rupture - Nature

More recently, it was revealed that the DNA from ruptured micronuclei can also act as a source of cytoplasmic DNA and trigger an innate immune ...

The multifaceted role of micronuclei in tumour progression: A whole ...

In this review, we discuss the further consequences of micronucleus formation, including how structural changes to the micronuclear envelope, and the rupturing ...

Micronuclei-based model system reveals functional consequences ...

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells.

Cell‐based model systems for genome instability: Dissecting the ...

16Kneissig M, Keuper K, de Pagter MS, et al. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells.

Image-based identification and isolation of micronucleated cells to ...

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife 8:e50292. doi:10.7554/elife.50292.

An image analysis approach to characterize micronuclei differences ...

M. Kneissig et al. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. eLife. ( ...

Chromosome length and gene density contribute to micronuclear ...

Micronuclei are derived from missegregated chromosomes and frequently lose membrane integrity, leading to DNA damage, innate immune ...

Mitotic clustering of pulverized chromosomes from micronuclei | Nature

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. eLife 8, e50292 (2019). Ly, P. & Cleveland ...

A cell‐based model system links chromothripsis with hyperploidy

The system is applied to reveal a large impact of chromothripsis on gene expression. ... functional consequences of this catastrophic DNA rearrangement process.

Request a detailed protocol - Bio-protocol

Research article. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Maja Kneissig et al. DOI: 10.7554/eLife ...

Chromothripsis: an emerging crossroad from aberrant mitosis to ...

M.S.. et al. (. 2019. ). Micronuclei-based model system reveals functional consequences of chromothripsis in human cells ... S.M.. et al. (. 2015. ). A cell-based ...

Chromosomal Rearrangements and Chromothripsis: The Alternative ...

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife 2019, 8, e50292. [Google Scholar] ...

Causes and consequences of micronuclei. - Abstract - Europe PMC

Micronuclei have long been linked to chromosome instability, genome rearrangements, and mutagenesis. They are frequently found in cancers, during senescence, ...

Causes and Consequences of Nuclear Envelope Rupture and DNA ...

Because micronuclei are capable of promoting genome instability, it is essential to understand the sources of DNA damage and the mechanism through which it ...

Small but strong: Mutational and functional landscapes of ...

Accumulating evidence suggests that micronuclei and main nuclei represent separate entities with respect to DNA replication, DNA damage sensing ...

Chromosome length and gene density contribute to micronuclear ...

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife 8:e50292. doi:10.7554/elife.50292.