Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis ...

Amyotrophic lateral sclerosis is a severe neurodegenerative disease whose exact cause is still unclear. Currently, research attention is ...

Amyotrophic lateral sclerosis is a severe neurodegenerative disease whose exact cause is still unclear. Currently, research attention is turning to the ...

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid ...

Pathological changes in ALS are closely associated with pronounced and progressive changes in mitochondrial morphology, bioenergetics and calcium homeostasis.

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are ...

The role of mitochondria in amyotrophic lateral sclerosis

Direct evidence that disruption of mitochondrial structure (and as a consequence function; see below) may contribute to the aetiology of ALS ...

Mitochondria, a Key Target in Amyotrophic Lateral Sclerosis ... - MDPI

Mitochondrial dysfunction occurs in numerous neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS), where it contributes to motor ...

Review Mitochondrial dysfunction in amyotrophic lateral sclerosis

In addition, dense conglomerates of mitochondria in the anterior horn of lumbar spinal cord and proximal axons have been found in sporadic ALS patients [31], [ ...

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), a type of motor neuron disease (MND), is a rapidly progressive, incurable and fatal neurodegenerative ...

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics - Frontiers

Amyotrophic lateral sclerosis (ALS) is a progressive and devastating multifactorial neurodegenerative disorder. Although the pathogenesis of ALS is still ...

Mitochondrial dysregulation occurs early in ALS motor cortex with ...

... familial and sporadic cases of amyotrophic lateral sclerosis (ALS). While same mitochondrial problems are present in the UMNs of ALS ...

Discrete mitochondrial aberrations in the spinal cord of sporadic ...

Mitochondrial dysfunction is a major contributor to motor neuron degeneration associated with ALS progression. Mitochondrial abnormalities have ...

Ultrastructural Mitochondrial Abnormalities in Patients With Sporadic ...

Higgins et al described vacuolated mitochondria in the early phases of motor neuron degeneration in transgenic mice with familial amyotrophic lateral sclerosis ...

Mitochondrial Alterations in the Spinal Cord of Patients With ...

Accumulating evidence shows that mitochondrial damage is involved in motor neuron degeneration in sporadic amyotrophic lateral sclerosis (ALS) (1-3), familial ...

Skeletal muscle dysfunction in amyotrophic lateral sclerosis

Skeletal muscle in ALS is primarily affected by oxidative stress, mitochondrial dysfunction, and bioenergetic abnormalities [3]. The brain is an ...

Mitochondrial Respiratory Chain Dysfunction in Muscle From ...

Background Amyotrophic lateral sclerosis (ALS) is a major cause of neurological disability and its pathogenesis remains elusive despite a multitude of ...

(PDF) Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral ...

Our data confirm changes in mitochondrial respiration in ALS patients, manifested by the reduced function of complex I and complex II of the ...

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral ...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal neurodegenerative disease. Although the pathogenesis of ALS ...

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal ...

Mitochondrial dysfunction in familial amyotrophic lateral sclerosis

A growing body of evidence suggests that mitochondrial dysfunctions play a crucial role in the pathogenesis of various neurodegenerative ...

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

Neuronal mitochondria dysfunction is one of the earliest features of ALS. Mitochondria are highly dynamic organelles that undergo continuous ...