Mitochondrial Metabolism in X|Irradiated Cells Undergoing ...

Mitochondrial Metabolism in X-Irradiated Cells Undergoing ...

Abstract. Irreversible cell-cycle-arrested cells not undergoing cell divisions have been thought to be metabolically less active because of the ...

Mitochondrial Metabolism in X-Irradiated Cells Undergoing ... - MDPI

In this study, we examined the mitochondria-dependent metabolism in human cells irreversibly arrested in response to ionizing radiation to confirm this ...

Mitochondrial Metabolism in X-Irradiated Cells Undergoing ... - MDPI

Mitochondrial Metabolism in X-Irradiated Cells Undergoing Irreversible Cell-Cycle Arrest · First of all, authors have used transformed cell line, thus not a ...

(PDF) Mitochondrial Metabolism in X-Irradiated Cells Undergoing ...

... Mitochondria regulate apoptosis and play an essential role in ROS generation during oxidative phosphorylation. Radiation exposure triggers ...

Inhibition of the mitochondrial fission protein dynamin-related ... - NCBI

Drp1 inhibition attenuates radiation-induced MC and increases cellular survival after x-irradiation. (A) Cells undergoing MC after x-irradiation. After WT MEFs ...

Mitochondrial and metabolic alterations in cancer cells - ScienceDirect

In fact, it has been demonstrated that the increase in metabolism and signaling functions, because of aberrant mitochondria functions such as in mitophagy, ...

Mitochondrial metabolism as a potential therapeutic target in ...

In fact, recent studies have shown that LSCs and treatment-resistant cells are dependent on mitochondrial metabolism, hence rendering them ...

Mitochondria at the crossroads of health and disease - Cell Press

Our understanding of the relevance of NAD+ metabolism for human health and diseases is increasing. In mice and humans with mitochondrial muscle disease, NAD+ ...

The Role of Mitochondrial Dysfunction in Radiation-Induced Heart ...

These factors include mitochondrial DNA mutations, oxidative stress, alterations in various mitochondrial function-related transcription factors ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune ...

Metabolic substrate uptake and mitochondrial metabolism form the foundational elements for T-cell activation, proliferation, differentiation, and effector ...

Ionizing radiation triggers mitophagy to enhance DNA damage in ...

Mitochondria, the powerhouse of cells, are easily damaged by ionizing radiation. Thus, transmission electron microscopy showed that in PANC-1 ...

Rewiring mitochondrial metabolism to counteract exhaustion of CAR ...

TM cells undergo accelerated mitochondria-mediated OXPHOS and FAO and slowed glycolysis and preferentially exhibit mitochondrial fusion and ...

Mitochondrial Metabolism as a Target for Cancer Therapy - Cell Press

Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the ...

Mitochondrial metabolic determinants of multiple myeloma growth ...

As MM cells sustain massive Ig synthesis, assembly, and secretion, they undergo substantial endoplasmic and oxidative stress. In fact, redox state in MM cells ...

Mitochondria as extranuclear targets of ionizing radiation

Accumulating evidence links mitochondrial dynamics and metabolism with cell proliferation and cell cycle regulation,and suggests that mitochondria play an ...

Mitochondrial homeostasis: shaping health and disease

Elevated mitochondrial oxidative metabolism is a well-established metabolic hallmark of leukemia (Chen et al. 2020). Leukemia cells exhibit ...

Mitophagy mediates metabolic reprogramming of induced ...

We hypothesized that during differentiation of human induced pluripotent stem cells (hiPSCs), mitochondria undergo mitophagy and are then ...

Mitochondrial Metabolism and Cancer

oncogenes and loss of function of tumor sup- pressors. There are six major alterations that normal cells undergo to become tumor cells.1. These alterations ...

Molecular and cellular mechanisms underlying the failure of ... - JCI

This is not surprising given that mitochondrial electron transport chain (ETC) function is necessary for the function of normal tissue, ...

Mitochondria and the dynamic control of stem cell homeostasis

Given their dynamic and multifaceted role in energy metabolism, redox, and calcium balance, as well as cell death, mitochondria appear at the interface between ...