Mitophagy in Cell Death Regulation

In this review, we provided an overview of the regulatory role of mitophagy in RCD including autophagic cell death (ACD), apoptosis, pyroptosis, necroptosis ...

Mitophagy in Cell Death Regulation: Insights into Mechanisms and ...

Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathway, and not only eliminates damaged mitochondria but also ...

The Role of Mitophagy in Regulating Cell Death - PMC

With overwhelming mitochondrial damage, the cell death pathway (necrosis, apoptosis, pyroptosis, ferroptosis and necroptosis) becomes dominant, ...

Mitophagy in Cell Death Regulation: Insights into Mechanisms and ...

Mitophagy, a selective form of autophagy, plays a crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular ...

Regulatory circuits of mitophagy restrict distinct modes of cell death ...

These results demonstrate that key pathways of mitophagy support memory T cell responses by limiting distinct forms of cell death.

The mitophagy pathway and its implications in human diseases

If ROS cannot be scavenged in time and accumulates in cells, it will result in apoptosis. Mitophagy maintains mitochondria in an optimal ...

Targeting cellular mitophagy as a strategy for human cancers

Excessive mitophagy leads to the loss of functional mitochondria, leading to insufficient energy supply and cell death. On the other hand, ...

Mitochondria and Mitophagy | Circulation Research - AHA Journals

The B-cell lymphoma (BCL)-2 family of proteins is at the center of mitochondrial apoptosis regulation. Antiapoptotic members such as BCL-2 and ...

Mitophagy, Mitochondrial Homeostasis, and Cell Fate - Frontiers

Mitochondrial fission was found to contribute to mitochondrial apoptosis and was also suggested to be a prerequisite for mitophagy, while mitochondrial fusion ...

Emerging role of mitophagy in human diseases and physiology

Despite mitophagy's role in the suppression of cell death by removing damaged mitochondria, upon high-stress conditions and the number of damaged mitochondria ...

Kill one or kill the many: interplay between mitophagy and apoptosis

Mitochondria are key players of cellular metabolism, Ca2+ homeostasis, and apoptosis. The functionality of mitochondria is tightly regulated ...

The role of mitophagy in innate immune responses triggered by ...

Besides apoptosis, mitochondria also control non-apoptotic types of programmed cell death, including regulated necrosis [74]. The mechanisms of ...

Mitochondrial Biogenesis, Mitophagy, and Mitophagic Cell Death in ...

For the betterment of mitochondrial homeostasis, a coordinated regulation is necessary between the genesis of functional and/or fresh ...

Mitophagy plays a “double-edged sword” role in the radiosensitivity ...

found that protein disulfide isomerase can inhibit radiotherapy-induced cell death by regulating mitophagy signaling, increasing cellular radio- ...

New insights into mitophagy and stem cells

MSCs protect tissues from cell death due to ischemia/reperfusion injury [39]. The synergistic regulation of mitochondrial biogenesis and ...

Involvement of mitophagy in cisplatin-induced cell death regulation

We show that stimulation of mitophagy suppressed cisplatin-induced apoptosis, while mitophagy inhibition stimulates apoptosis and autophagy.

Mitophagy: Link to cancer development and therapy - ScienceDirect

Pathways involved in the regulation of mitophagy, tumorigenesis, and cell death are overlapping in many cases and may be triggered by common upstream ...

Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis

Degradation of defective mitochondria is an essential process to maintain cellular homeostasis and it is strictly regulated by the ...

The Mitochondrial Dynamism-Mitophagy-Cell Death Interactome

To prevent mitochondrial contagion, cells use mitophagy to identify, functionally sequester, and remove severely damaged mitochondria (Figure 1B) ...

Molecular Mechanisms and Regulation of Mammalian Mitophagy

Failure of these quality control mechanisms leaves mitochondria as terminally damaged, which then have to be promptly cleared from the cells before they become ...