Modelling acute antibody|mediated rejection of human kidney ...

Modelling acute antibody-mediated rejection of human kidney ...

Using 12 human kidneys and ex-vivo normothermic machine perfusion, we demonstrate phenotypes of AMR after addition of antibodies against either human HLA class ...

Modelling acute antibody-mediated rejection of human kidney ...

Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion

(PDF) Modelling acute antibody-mediated rejection of human kidney ...

PDF | Background Transplant rejection is a major cause of graft loss and morbidity. Currently, no human models of antibody-mediated ...

Researchers successfully model antibody-mediated transplant ...

Researchers successfully model antibody-mediated transplant rejection in human kidneys ... Read the full paper, 'Modelling acute antibody-mediated ...

Mechanisms of antibody-mediated acute and chronic rejection of ...

... acute rejection episodes in kidney transplant patients and more than ... However, several new mouse models of antibody-mediated kidney allograft rejection ...

Researchers successfully model antibody-mediated transplant ...

Researchers successfully model antibody-mediated transplant rejection in human kidneys ... Modelling acute antibody-mediated rejection of ...

Acute antibody-mediated rejection in kidney transplant recipients

Over the past two decades, new animal models, diagnostic techniques, and clinical experience have informed an evolving understanding of this disease, its ...

A Sensitized Rat Model of Acute Antibody-Mediated Rejection

A Sensitized Rat Model of Acute Antibody-Mediated Rejection of Kidney Allografts. ... RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes ...

Modelling acute antibody-mediated rejection of human kidney ...

Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion ... Lefaucheur, Determinants of poor graft outcome in ...

Molecular Diagnosis of Antibody-Mediated Rejection in Human ...

The clinical importance of antibody in organ transplantation became apparent with the description of hyperacute rejection of kidney transplants in recipients ...

Summary of 2017 FDA Public Workshop - Transplantation

Antibody-mediated Rejection in Kidney Transplantation. Velidedeoglu, Ergun MD 1; Cavaillé-Coll, Marc W. MD, PhD 1; Bala, Shukal PhD ...

Antibody Mediated Rejection in Kidney Transplantation; Public ...

The Food and Drug Administration (FDA) is announcing a public workshop regarding new developments and scientific issues related to antibody mediated rejection ...

Antibody-Mediated Rejection (ABMR) - Wiley Online Library

Animal models. · The HLA antibody phenotype. · The histopathology phenotypes of kidney transplant biopsies. · ABMR phenotypes in biopsies of other organs.

Antibody-mediated rejection across solid organ transplants - JCI

NK cells and their associated transcripts are increased in human renal, cardiac, and lung allografts during AMR (122–126) and mediate acute and ...

Emerging Therapies for Antibody-Mediated Rejection in Kidney ...

Its effectiveness in humans was studied only in lung and heart transplant recipients who had acute AMR with promising results [19,20]. But there are no data yet ...

Transcriptomic signatures of chronic active antibody-mediated ...

To fill these gaps, we RNA sequenced human kidney allograft biopsies categorized as CA-ABMR, active-ABMR, TCMR, or No Rejection (NR). Among the ...

Tocilizumab and Active Antibody-Mediated Rejection in Kidney ...

Up to one-third of highly sensitized recipients may develop acute ABMR (aABMR) following transplantation, even in those that have undergone a ...

Application of the Banff Human Organ Transplant Panel to kidney ...

This model can be used to identify biopsies at a higher risk of graft loss. Antibody-mediated rejection (AMR) is the leading cause of late ...

Mouse Model Established by Early Renal Transplantation After Skin ...

Antibody-mediated rejection (AMR) has been recognized as the leading cause of kidney graft failure, which accounts for 30–50% of acute rejection episodes in ...

Enzymatic conversion of human blood group A kidneys to universal ...

This converts the organ to a non-immunogenic state, permitting transplantation without risk of hyperacute antibody-mediated rejection. Such ...