Modification in the Expression of MRE11/RAD50/NBS1 Complex in ...

Modification in the Expression of Mre11/Rad50/Nbs1 Complex in ...

The role of MRN complex has been extensively studied at relatively higher doses of radiation but the studies at LDR are inadequate. Therefore, expression of ...

Modification in the expression of Mre11/Rad50/Nbs1 complex in low ...

Despite the fact that high doses of radiation are detrimental, low dose radiation (LDR) often protects the organism against a subsequent ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

Through interacting with other important players of DNA damage response, MRE11-RAD50-NBS1 complex is engaged in various DNA damage repair ...

Modification in the Expression of MRE11/RAD50/NBS1 Complex in ...

Modification in the Expression of MRE11/RAD50/NBS1 Complex in Low dose Irradiated Human Lymphocytes · Sompal Singh, M. Bala, +2 authors. SC Dhiman · Published in ...

Untangling the clinicopathological significance of MRE11-RAD50 ...

The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer ...

Mutations in genes and altered expression of proteins of the MRN ...

For other NBS1 as well as MRE11 and RAD50 variants, too little data were available to assess their role in cancer risk. Overall, the results suggest that ...

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...

Abstract. Background: The MRN complex of meiotic recombination 11 (MRE11), DNA repair protein Rad50. (RAD50) and Nijmegen breakage syndrome 1 (NBS1).

RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN ...

The Mre11-Rad50-NBS1 (MRN) complex plays an important role in the DNA damage response pathway; it is first recruited to DSB sites and acts as a ...

Post-Translational Modification of MRE11: Its Implication in DDR ...

Meiotic recombination 11 (MRE11), the key components of the MRE11-RAD50-NBS1 (MRN) complex which function mainly to activate ATM- or ATR-mediated DNA damage ...

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote ...

To further test whether any DNA modification by MRN, including resection, ... the expression of WT MRE11 (Figure 3C). In ... Direct activation of ...

(PDF) MRE11-RAD50-NBS1 complex alterations and DNA damage ...

Through interacting with other important players of DNA damage response, MRE11-RAD50-NBS1 complex is engaged in various DNA damage repair pathways. Mutations in ...

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in ...

The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles ...

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation ...

We have identified B-Myb as a novel interaction partner of the Mre11-Rad50-Nbs1 (MRN) complex, a key player in the repair of DNA double strand ...

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...

Background: The MRN complex of meiotic recombination 11 (MRE11), DNA repair protein Rad50 (RAD50) and Nijmegen breakage syndrome 1 (NBS1) proteins coordinate ...

Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor ...

The MRE11, RAD50, and NBS1 genes encode proteins of the MRE11–RAD50–NBS1 (MRN) complex critical for proper maintenance of genomic integrity ...

C1QBP Promotes Homologous Recombination by Stabilizing ...

MRE11 nuclease forms a trimeric complex (MRN) with RAD50 and NBS1 and plays a central role in preventing genomic instability.

MRE11 and RAD50, but not NBS1, are essential for gene targeting ...

The MRN complex is one of the earliest respondents to DNA-DSBs and plays a central role in controlling repair pathway choice between NHEJ and HR ( 5 ). The ...

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and ...

The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ... - OUCI

This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage.

Breast Cancer Risk Is Associated with the Genes Encoding the DNA ...

Abstract. The evolutionarily conserved Mre11-Rad50-Nbs1 (MRN) complex, consisting of proteins encoded by the genes Mre11, Rad50, and Nbs1, was recently.