Modified SOX decoys potently inhibit DNA binding of SOX18. The ...

Modified SOX decoys potently inhibit DNA binding of SOX | Open-i

The potency to inhibit binding of 50 nM SOX18-HMG to 20 nM cy5-labelled Prox1-DNA by three decoys was assessed by EMSAs using decoy concentrations 500, 250, 125 ...

Modified SOX decoys potently inhibit DNA binding of SOX18. The potency to inhibit binding of 50 nM SOX18-HMG to 20 nM cy5-labelled Prox1-DNA by three decoys ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability, nuclease resistance and ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

This SOX decoy also interfered with the expression of a luciferase reporter under control of a SOX18-dependent VCAM1 promoter in COS7 cells.

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability, nuclease resistance and thermal ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability, nuclease resistance and thermal ...

Article Small-Molecule Inhibitors of the SOX18 Transcription Factor

More recently, SOX-DNA decoys have been used as selective inhibitors of SOX18 DNA-binding and SOX18-dependent transactivation. While these decoys display great ...

Molecular Mechanism of Nucleosome Recognition by the Pioneer ...

... decoys based on modified Prox1-DNA. Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs.

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

... decoys based on modified Prox1-DNA. Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

We identified two compounds, which inspired a series of synthetic SOX18 inhibitors, able to interfere with the SOX18 HMG DNA-binding domain, and to disrupt HMG- ...

Inhibitors of SOX18 protein activity to treat angiogenesis- and / or ...

Thus, there remains a need for compounds that inhibit SOX18 protein activity either directly by binding to it or by approaching its DNA binding domain, such as ...

Inhibitors of SOX18 protein activity for treating angiogenesis-and/or ...

Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with ...

Anticancer HIF decoys(Anesiva) - Drug Targets, Indications, Patents

To explore alternatives to challenging small molecule approaches for targeting the DNA-binding activity of SOX18, we designed a set of five decoys based on ...

Post-translational modification of SOX family proteins

Okadaic acid can broadly inhibiting serine/threonine phosphatases and results in an increase in Sox18 transcriptional activity. Sox18 transcriptional activity ...

(PDF) Exploring the utility of organo-polyoxometalate hybrids to ...

Related papers. Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction ... potent in inhibiting transcription factor DNA binding activity.

Homodimerization regulates an endothelial specific signature of the ...

SOX18 binding sites and a putative secondary SOX ... (2016) Structure and decoy-mediated inhibition of the. SOX18/Prox1-DNA interaction.

Exploring the utility of organo-polyoxometalate hybrids to inhibit ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction ... The crystal structure of the SOX18 DNA binding ... SOX/DNA complex presently ...

Post-translational modification of SOX family proteins_ Key ... - CORE

those reported PTMs of Sox proteins which influence DNA binding ... inhibition of the SOX18/Prox1-DNA interaction, Nucleic Acids Res. ... Yuasa, Inhibition of DNA ...

Engineering Critical Residues of SOX9 Discovers a Variant ... - OUCI

Williams, Post-translational modification of SOX ... Klaus, Structure and decoy-mediated inhibition of the SOX18/ Prox1 -DNA interaction, Nucleic Acids Res., с.

SOX7 IS DOWNREGULATED AND FUNCTIONS AS A TUMOR ...

Although SOX7 shares its DNA binding element with many other SOX proteins, it has ... inhibiting its DNA-binding abilities. To this end ... modify RNA-binding ...