Molecular Biology of Childhood Leukemia

Molecular Biology of Childhood Leukemia - Annual Reviews

Childhood hematological malignancies (HM) exhibit profound genetic and biological heterogeneity. Many sporadic and familial HM have a ...

Molecular genetics of childhood leukemias - PubMed

Although clinical features are important prognostic indicators, genetic alterations of leukemic blasts may be better predictors of outcome for acute ...

Molecular genetics, natural history and the demise of childhood ...

These are the 'bad news' genotypes. The cellular and molecular diversity of acute leukaemia impacts also on aetiology. Paediatric acute leukaemias can be ...

The genomic landscape of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2754 ...

A causal mechanism for childhood acute lymphoblastic leukaemia

Childhood acute leukaemia is the most common paediatric cancer in developed societies, accounting for one-third of all cases, with a variable ...

Biology of Childhood Leukemia – CIRCLE

When leukemia strikes, it's because the bone marrow is producing unhealthy, immature B cells, which have too many or too few methyl groups ...

Molecular Biology of Childhood Leukemia - SUNY New Paltz

We provide an overview of the molecular foundation and classification of childhood leukemias, focusing on recent scientific advances, and discuss potential ...

The Prenatal Origin of Childhood Leukemia - Frontiers

Childhood leukemias are heterogeneous diseases with widely differing incident rates worldwide. As circulating tumors, childhood acute leukemias ...

Pediatric acute lymphoblastic leukemia - Haematologica

The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic ...

Molecular Biology of Childhood Leukemia | Request PDF

Childhood hematological malignancies (HM) exhibit profound genetic and biological heterogeneity. Many sporadic and familial HM have a ...

Biology of Childhood Leukaemia Group - Institute of Cancer Research

Professor Mel Greaves' Biology of Childhood Leukaemia Group is funded by The Kay Kendall Leukaemia Fund and Leukaemia & Lymphoma Research and seeks to uncover ...

Biology of pediatric leukemia - Current research - Gustave Roussy

While recurrent genetic alterations have been identified in the past years, functional analyses are now required to identify how a normal cell become leukemic, ...

What Causes Childhood Leukemia? - American Cancer Society

The combination of genetics and exposure might increase their risk for leukemia. Some research suggests that some childhood leukemias might be ...

Molecular epidemiology of acute leukemia in children: causal model ...

Acute leukemias have a huge morphological, cytogenetic and molecular heterogeneity and genetic polymorphisms associated with susceptibility.

Prenatal Origin of Pediatric Leukemia: Lessons From Hematopoietic ...

These observations raise the hypothesis that HSC-independent progenitors arising at the embryonic level could be subject to genetic hits leading ...

Leukemia in Children | Memorial Sloan Kettering Cancer Center

Our clinical genetics experts can help you and your family understand the role of genetics in your child's leukemia and whether any genetic mutations may affect ...

Biological Markers of High-Risk Childhood Acute Lymphoblastic ...

The bottom row categorizes various high-risk immunophenotypes including early T-cell precursor ALL (ETP-ALL) and mixed phenotype acute leukemia (MPAL), along ...

Molecular analysis of childhood B-acute lymphoblastic leukemia

Acute lymphoblastic leukaemia (ALL) is the most common subtype of childhood cancer. Detection of a specific gene rearrangement allows the ...

Childhood Acute Lymphoblastic Leukemia - NCI

And it will develop in some children who don't have a known risk factor. Risk factors may be genetic or due to other causes. Possible genetic ...

Molecular biology and childhood leukemia: E2APBX1 and central ...

One of the best studied gene rearrangements is E2A-PBX1, which predicts isolated central nervous system relapse in patients with ALL. However, further research ...