Molecular Characteristics of Cisplatin|Induced Ototoxicity and ...

Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

Cisplatin-induced ototoxicity manifests as irreversible, bilateral, high-frequency sensorineural hearing loss in 40-60% of adults and in up to ...

Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

Cisplatin-induced ototoxicity is characterized by bilateral, moderate-to-profound high-frequency hearing loss, and a significant loss of outer ...

(PDF) Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

Cisplatin-induced ototoxicity manifests as irreversible, bilateral, high-frequency sensorineural hearing loss in 40–60% of adults and in up to ...

Cisplatin-induced ototoxicity: Updates on molecular mechanisms ...

The incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss.

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

There is a 5-fold increase in the risk of hearing impairment or ototoxicity with cisplatin, which can manifest as ringing in the ear (tinnitus), high-frequency ...

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

Cisplatin entry into cochlear hair cells is mediated by various transporters, inhibitors of which have been shown to be effective for treating hearing loss.

Current Understanding of Membrane Transporters as Regulators or ...

Cisplatin-induced ototoxicity is the result of cochlear hair cell damage through a mechanism that is poorly understood. However, cisplatin ...

Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

This narrative review aims to highlight the molecular mechanisms involved in cisplatin-induced ototoxicity, focusing on cochlear inflammation, and shed light on ...

A potential therapeutic approach for cisplatin-induced hearing loss

Several molecules that can prevent excessive ROS or apoptosis have been identified for the treatment of cisplatin-induced ototoxicity.

Cisplatin ototoxicity mechanism and antagonistic intervention strategy

This article reviews the possible pathways and molecular mechanisms of cisplatin trafficking from peripheral blood into the inner ear, the toxic response of ...

Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection ...

Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that ...

Subclinical diagnosis of cisplatin-induced ototoxicity with biomarkers

Prestin was significantly elevated in the serum before the onset of objective hearing loss and correlated with the severity of hearing damage ...

Cisplatin‐Associated Ototoxicity: A Review for the Health Professional

Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this ...

The genetic vulnerability to cisplatin ototoxicity: a systematic review

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II).

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

Fetoni AR, Paciello F, Troiani D: Cisplatin chemotherapy and cochlear damage: Otoprotective and chemosensitization properties of polyphenols.

Progress in the Development of Preventative Drugs for Cisplatin ...

A single intratympanic injection of 6% OTO-104 a day before cisplatin treatment was effective in protecting against cisplatin ototoxicity, even ...

Prevention and Restoration of Hearing Loss Associated with the Use ...

Inclusion criteria were cisplatin-induced ototoxicity and therapy aimed at preventing or curing this disorder. Molecular mechanisms and clinical ...

Reversible p53 inhibition prevents cisplatin ototoxicity without ...

To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We ...

Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies

Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. This review summarizes recent important ...

Article Versions Notes - MDPI

Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions. International Journal of Molecular Sciences. 2023; 24(22):16545 ...