Molecular Heterogeneity in Leiomyosarcoma and Implications for ...

Leiomyosarcoma (LMS) is one of the more common subtypes of soft tissue sarcomas (STS), accounting for about 20% of cases.

Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the most common subtypes of soft tissue sarcomas. It is ...

Discovery of molecular subtypes in leiomyosarcoma through ...

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We employed integrative molecular ...

Molecular Heterogeneity in Leiomyosarcoma and Implications for ...

Comprehensive and integrated genomic characterization of adult soft tissue sarcomas. Cell. 2017;171:950-965.e28. Integrated genomic and transcriptomic analysis ...

Heterogeneity in the gene regulatory landscape of leiomyosarcoma

Abstract. Characterizing inter-tumor heterogeneity is crucial for selecting suitable cancer therapy, as the presence of diverse molecular subgroups of pati.

The biology and treatment of leiomyosarcomas - ScienceDirect.com

Leiomyosarcomas encompass tumours of histological, clinical and molecular heterogeneity. ... meaning that IHC staining for smooth muscle markers should be ...

Heterogeneity in the gene regulatory landscape of leiomyosarcoma

Characterizing inter-patient molecular tumor heterogeneity was shown to be crucial for selecting the most efficient cancer therapy, and the ...

Clinically Relevant Molecular Subtypes in Leiomyosarcoma

Little is known about its molecular heterogeneity and no targeted therapy currently exists for leiomyosarcoma. Recognition of different molecular subtypes ...

Lineage-defined leiomyosarcoma subtypes emerge years before ...

Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not ...

Targeting the Molecular and Immunologic Features of ... - MDPI

Soft tissue sarcomas (STS) are a heterogeneous group of more than 50 different types of rare mesenchymal tumors [1]. Leiomyosarcoma (LMS) is one of the most ...

Distinct molecular subtypes of uterine leiomyosarcoma respond ...

Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well ...

Molecular subtypes of leiomyosarcoma: Moving toward a consensus

Due to advancements in gene expression profiling technologies, our understanding of the molecular basis of LMS has improved over the past decade ...

Therapeutic advances in leiomyosarcoma - Frontiers

It is characterized by significant disease heterogeneity with variable sites of origin and diverse genomic profiles. As a result, the treatment ...

Molecular mechanisms underpinning sarcomas and implications for ...

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity ...

Clinically Relevant Molecular Subtypes in Leiomyosarcoma

Purpose: Leiomyosarcoma is a malignant neoplasm with smooth muscle differentiation. Little is known about its molec- ular heterogeneity and no targeted ...

Molecular subtypes of leiomyosarcoma: Moving toward a consensus

Here we show that at the protein level, LMS can be distinguished into three proteomic subtypes. ... ... It has previously been shown that UPS- ...

Gene expression profiling identifies distinct molecular subgroups of ...

Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine. · Medicine. Current treatment options in oncology · 2024.

Genetic and Molecular Heterogeneity of Synovial Sarcoma ... - MDPI

Synovial sarcoma (SS) accounts for 4–10% of all soft tissue sarcoma (STS) subtypes, being the fourth most frequent cancer after liposarcoma (26%), ...

Clinical implications of intratumor heterogeneity: challenges and ...

Molecular heterogeneity: a genomic substrate for both tumor biology and evolution ... During the 1990s, and after the discovery of oncogenes, it ...

Germ Cell Tumor Molecular Heterogeneity Revealed Through ...

Analysis of paired primary and metastatic GCT specimens revealed significant molecular heterogeneity for both CNAs and somatic mutations.