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Molecular Mechanisms Affecting Fibrin Structure and Stability


Molecular mechanisms affecting fibrin structure and stability - PMC

Because thrombin activates FXIII when both proteins are bound to fibrin, the conversion of fibrinogen to fibrin and the formation of covalent bonds between ...

Molecular mechanisms affecting fibrin structure and stability - PubMed

Fibrin structure and stability have been linked to many thrombotic diseases, including venous thromboembolism. Analysis of the molecular mechanisms that ...

Molecular Mechanisms Affecting Fibrin Structure and Stability

Abstract. Fibrin structure and stability have been linked to many thrombotic diseases, including venous thromboembolism. Analysis of the ...

Molecular Mechanisms Affecting Fibrin Structure and Stability ...

Fibrin structure and stability have been linked to many thrombotic diseases, including venous thromboembolism. Analysis of the molecular mechanisms that ...

Structure of fibrin: impact on clot stability - ScienceDirect.com

The biochemical basis of fibrinolysis involves the binding of circulating plasminogen to fibrin and its activation to plasmin by tissue-type plasminogen ...

Mechanisms of fibrin polymerization and clinical implications | Blood

The mechanical and chemical stability of clots and thrombi are affected by both the structure of the fibrin network and cross-linking by plasma transglutaminase ...

New insights into the molecular mechanisms of the fibrinolytic system

Structure of fibrin: impact on clot stability. J Thromb. Haemost 2007; 5 (Suppl. 1): 116–24. 50 Miles LA, Dahlberg CM, Plescia J, Felez J, Kato K, Plow EF ...

Fibrin structure and wound healing - ScienceDirect.com

Binding of FXIII affects the fibrin matrix structure by increasing the tensile strength and stability of the clot [36, 37, 38]. The fibrinous matrix of a wound ...

Fibrin Clot Structure and Function - AHA Journals

A common β-chain polymorphism, Lys448Arg, has been shown to affect clot structure in plasma, Recombinant Lys448 and Arg448 fibrinogens also ...

Structural control of fibrin bioactivity by mechanical deformation

We find that tensile deformation of fibrin leads to molecular structural transitions of α-helices to β-sheets, which reduced binding of tissue ...

Molecular and Physical Mechanisms of Fibrinolysis and ... - Nature

Fibrin clot structure is affected by the environment in which it forms; importantly, high thrombin concentrations result in fine clots with ...

NAVER Academic > Articles

Molecular mechanisms affecting fibrin structure and stability. Author: Susan T Lord; Journal: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY ISSN 1079-5642

Molecular mechanisms affecting fibrin structure and stability - Wikidata

Molecular mechanisms affecting fibrin structure and stability (English). 1 reference. stated in · Europe PubMed Central · PubMed publication ID · 21325671.

Engineered Molecular Therapeutics Targeting Fibrin and the ...

By forming the key protein component of blood clots, fibrin acts as a structural biomaterial with biophysical properties well suited to its role ...

Fibrinogen and fibrin: An illustrated review

Fibrin formation, structure, and stability are regulated by various genetic, biochemical, and environmental factors, allowing for dynamic kinetics of fibrin ...

Post-translational modifications of fibrinogen: implications for clotting ...

The γ chain contains a number of sites that interact with other fibrin(ogen) molecules, clotting factors, growth factors, and integrins. A minor ...

Molecular Mechanisms Affecting Fibrin Structure and Stability

Molecular Mechanisms Affecting Fibrin Structure and Stability by Susan T. Lord published in Arteriosclerosis, Thrombosis, and Vascular Biology.

Modulating the rate of fibrin formation and clot structure attenuates ...

We used confocal microscopy to analyze the fibrin clot structure in plasma from healthy humans and endotoxemic mice, turbidity assays to examine ...

Fibrin Formation, Structure and Properties. - Semantic Scholar

... molecular mechanisms offibrin formation, its organization, and properties ... Molecular packing structure of fibrin fibers resolved by X-ray scattering and ...

Molecular mechanisms of initiation of fibrinolysis by fibrin

Recent studies with recombinant and proteolytic fibrin(ogen) fragments clarified the molecular mechanisms by which these sites become exposed. Namely, upon ...