Molecular Signaling Pathways and Therapeutic Targets in ...

In this review, we elaborated on our current understanding of the signaling pathways involved in the development and initiation of HCC and anticipate the ...

Molecular Signaling Pathways and Therapeutic Targets in ... - PubMed

Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at advanced stages with no effective treatment options ...

Signaling pathways and therapeutic interventions in gastric cancer

Modern molecular classifications have uncovered the vital roles that signaling pathways, including EGFR/HER2, p53, PI3K, immune checkpoint ...

[PDF] Molecular Signaling Pathways and Therapeutic Targets in ...

The current understanding of the signaling pathways involved in the development and initiation of HCC is elaborated and the potential targets for ...

Emerging Molecular Signaling Pathways and Therapeutic Targets ...

Emerging Molecular Signaling Pathways and Therapeutic Targets for Genitourinary Cancer Metastasis · 27k. Total Downloads · 74k. Total Views and Downloads.

Therapeutic approaches targeting molecular signaling pathways ...

We report common signaling pathways (eg: TGF-β, IL-6, HIF-1, PDGF) and miRNAs that are dysregulated in DM and LC and serve as molecular targets for therapy.

Signaling pathways and targeted therapy for myocardial infarction

Therefore, in this review, we explore the roles of several key signaling pathways in MI: PI3K/Akt, Notch, TGF-β/SMADs, Wnt/β-catenin, NLRP3/ ...

Emerging Molecular Signaling Pathways and Therapeutic Targets ...

Targeted therapies remain a significant need in prostate cancer; identifying and characterizing such pathways are critical for better overcoming resistance to ...

Investigating regulated signaling pathways in therapeutic targeting ...

The signaling cascades are stimulated via genetic modifications in upstream signaling molecules, which affect apoptotic, proliferative, and differentiation ...

Regulation and signaling pathways in cancer stem cells

The maintenance of CSC characteristics plays a pivotal role in driving CSC-associated tumor metastasis and conferring resistance to therapy.

Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial ...

Molecular alterations in cancer genes and associated signaling pathways are used to inform new treatments for precision medicine in cancer.

Molecular Signaling Pathways as Potential Therapeutic Targets in ...

In recent years, diverse signaling pathways have drawn the attention of the scientific community since they can be great candidates for treating complicated ...

interactive discovery of therapeutic targets using signaling pathway ...

We recently proposed the use of mechanism-based biomarkers derived from models of cell signaling activity that account for disease mechanisms or ...

Multiple myeloma: signaling pathways and targeted therapy

Overall, the activation of the PI3K/AKT/mTOR pathway in MM cells, coupled with interactions within the bone marrow microenvironment, leads to ...

Apoptosis in cancer: Key molecular signaling pathways and therapy ...

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Source: Springer Science and ...

Hepatocellular carcinoma: signaling pathways, targeted therapy ...

The signaling molecules related to Hh pathway are usually overexpressed in HCC, and this pathway is associated with tumor metastasis and ...

Use of signaling pathways as therapeutic targets for blood cancer

In this article, we will discuss the general concept of targeting signaling pathways in cancers and the limitations of this strategy, with a ...

Signaling pathways in colorectal cancer: implications for the target ...

Various biological molecules, such as epidermal growth factors, sonic hedgehog, IGF-1, insulin, and calmodulin, activate this signaling pathway.

Molecular Pathways: The Balance between Cancer and the Immune ...

Target gene profiles are highly tissue specific, thus presenting possible opportunities for directed therapy. Coactivators and corepressors at the ...

Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial ...

An up-to-date review of the successes and limitations of current targeted therapies for cancer treatment is provided and how recent technological advances ...