Molecular basis of FIGNL1 in dissociating RAD51 from DNA and ...

Our study reveals a unique mechanism for removing RAD51 from DNA and provides the molecular basis for FIGNL1 in maintaining genome stability.

Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in ...

Molecular basis of FIGNL1 in dissociating RAD51 from DNA ... - NCBI

Our study reveals a unique mechanism for removing RAD51 from DNA and provides the molecular basis for FIGNL1 in maintaining genome stability.

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and ...

To understand how FIGNL1's ATPase activity is linked to modulating RAD51's association with chromatin, we set out to investigate the molecular ...

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and ...

One of these regulators is FIGNL1, that prevents persistent RAD51 foci post-damage and genotoxic chromatin association in cells. The cryogenic ...

Molecular basis of FIGNL1 in dissociating RAD51 from DNA ... - OUCI

One of these regulators is FIGNL1, that prevents persistent RAD51 foci post-damage and genotoxic chromatin association in cells. The cryogenic electron ...

EMDR : EMD-18946 - EMDataResource

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin. Carver A, Yu TY, Yates LA, White T, Wang R, Lister K, Jasin M, Zhang X BioRxiv (2024) ...

FIGNL1-FIRRM is essential for meiotic recombination and prevents ...

During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA ...

biorxiv_biochem on X: "Molecular basis of FIGNL1 in dissociating ...

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin https://t.co/f5tmFGQCBD #biorxiv_biochem.

Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra ...

FIGNL1 knockout human cells were defective in RAD51 dissociation after replication fork restart and accumulated ultra-fine chromosome bridges (UFBs).

FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in ...

The resulting RAD51/DMC1-filaments mediate homology search and strand invasion to form Displacement-loops (D-loops) between DNA molecules, i.e. ...

Cryo-EM data collection, refinement and validation statistics

RAD51 recombinase, the central player of several crucial processes in repairing and protecting genome integrity, forms filaments on DNA. RAD51 filaments are ...

FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 ...

Combined, our data suggest that inactivation of FIRRM and FIGNL1 dysregulates RAD51 dynamics at replication forks, resulting in persistent DNA ...

FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin ...

We posit that FLIP is essential for limiting RAD51 levels on chromatin in the absence of damage and for RAD51 dissociation from nucleofilaments to properly ...

C1orf112 teams up with FIGNL1 to facilitate RAD51 filament ...

Specifically, C1orf112 physically interacts with FIGNL1 and enhances its protein stability. Meanwhile, the RAD51 filament disassembly activity ...

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly ...

While the stability of FIGNL1 and FIRRM is interdependent, expression of a mutant of FIRRM (∆WCF), which stabilizes the protein in the absence ...

Reconstitution of the antagonistic effect between C1orf112/FIRRM ...

Thus, it will be interesting to investigate whether FIRRM can dissociate RAD51 filament and the relationship among FIRRM, FIGNL1 and BRCA2 in ...

The FLIP-FIGNL1 complex regulates the dissociation of RAD51 ...

Thereafter RAD51/DMC1 dissociate, actively or passively, from these joint molecules upon DNA ... Molecular basis of FIGNL1 in dissociating RAD51 from DNA and ...

C1orf112 teams up with FIGNL1 to facilitate RAD51 filament ...

The recombinase RAD51 plays a core role in DNA repair by homologous recombination (HR). The assembly and disassembly of RAD51 filament need ...

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