Molecular mechanisms in the pathogenesis of dengue infections

We discuss the molecular mechanisms of dengue pathogenesis, the gaps in our knowledge, and recent advances, as well as the most crucial questions to be ...

Molecular mechanism of pathogenesis of dengue virus: Entry and ...

Interaction with specific receptor(s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known ...

Dengue virus pathogenesis and host molecular machineries

During dengue infection, the virus interacts with the host cellular machinery responsible for 5' capping. DENV employs multiple strategies to ...

Dengue Virus Pathogenesis: an Integrated View - ASM Journals

Although severe hepatic damage is not common in DENV infections, elevated liver enzymes suggest that the liver is affected, but the role of ...

Neelika Malavige on LinkedIn: Molecular mechanisms in the ...

Happy to share our review on #dengue pathogenesis. We discuss the molecular mechanisms of dengue pathogenesis, the gaps in our knowledge, ...

Molecular mechanisms in the pathogenesis of dengue infections

Dengue NS1 antigen, cytokines such as IL-1β, TNF-α, and IL-6, lipid mediators such as platelet-activating factor (PAF), leukotrienes and prostaglandins, VEGF, ...

Current Understanding of the Pathogenesis of Dengue Virus Infection

Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with ...

Recent Insights Into the Molecular Mechanism of Toll-Like Receptor ...

The pathogenesis of dengue is immune-mediated and complex, and regulatory T cells (Tregs) may suppress the immune response and contribute to better prognosis. A ...

Molecular mechanisms in the pathogenesis of dengue infections

A stress response elicits neuroendocrine and immune reactions that may lead to multi-organ dysfunction. The degree of neuroinflammatory reflex ...

Dengue Virus: Molecular Biology and Recent Developments in ...

Several host and viral factors play roles in dengue pathogenesis, including variation of the DENV genome, subgenomic RNA, NS1 viral antigen, ...

Dengue virus infection: Pathogenesis - UpToDate

Immune response and viral clearance — Both innate and adaptive immune responses induced by DENV infection are likely to play a role in the ...

Molecular Mechanisms of Antiviral Agents against Dengue Virus

During a DENV infection, the viral membrane exposed PtdSer, and this enabled virus entry into host cells by direct binding to the TIM receptor or indirect ...

Immune-Mediated Pathogenesis in Dengue Virus Infection - MDPI

These molecules are involved in disease severity in DENV-infected patients along with endothelial cells and platelet activation and mediate ...

Molecular Mechanisms Involved in Antibody‐Dependent ...

The generally accepted hypothesis explaining the immunopathogenesis of severe dengue is called antibody-dependent enhancement of dengue ...

Dengue virus: pathogenesis and potential for small molecule inhibitors

During the initial viral infection in dengue, the virus spreads quickly across the host's circulatory system, resulting in systemic dissemination. This phase is ...

Pathogenesis of Dengue: Challenges to Molecular Biology - Science

This antibody-dependent enhancement of infection regulates dengue disease in human beings, although disease severity may also be controlled ...

Dengue virus: epidemiology, biology, and disease aetiology

Production of interferons (IFNs) is considered to be the first defense mechanism in DENV-infected cells (Rodenhuis-Zybert et al. 2010). DENV first infects ...

New Perspectives on Dengue Pathogenesis - SciELO

Dengue viral infections represent a major concern for public health. Yet, the mechanisms of dengue virus (DENV) pathogenesis are not understood very well yet, ...

Neelika Malavige on X: "Happy to share our review on #dengue ...

... mechanisms of dengue pathogenesis, the gaps in our knowledge, and recent advances. Molecular mechanisms in the pathogenesis of dengue infections.

Dengue Infection - Recent Advances in Disease Pathogenesis in the ...

Figure 2 Proposed mechanism of evasion of DENV and DENV-infected cells from classical and lectin pathway-mediated complement attack in the host. NS1 protein ...