Molecular subtypes of leiomyosarcoma

Lineage-defined leiomyosarcoma subtypes emerge years before ...

Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle differentiation, which accounts for 10–20% of sarcoma diagnoses. The heterogeneity ...

Clinically relevant molecular subtypes in leiomyosarcoma - PMC

Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy ...

Clinically Relevant Molecular Subtypes in Leiomyosarcoma

A leiomyosarcoma tissue microarray with known clinical outcome was used to show that subtype I leiomyosarcoma is associated with good outcome in extrauterine ...

Clinically Relevant Molecular Subtypes in Leiomyosarcoma - PubMed

A leiomyosarcoma tissue microarray with known clinical outcome was used to show that subtype I leiomyosarcoma is associated with good outcome in ...

Molecular subtypes of leiomyosarcoma: Moving toward a consensus

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Targeting the Molecular and Immunologic Features of ... - MDPI

Leiomyosarcoma (LMS) is a rare, aggressive mesenchymal tumor with smooth muscle differentiation. LMS is one of the most common histologic subtypes of soft ...

Discovery of molecular subtypes in leiomyosarcoma through ...

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity.

Distinct molecular subtypes of uterine leiomyosarcoma respond ...

Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well ...

Molecular subtypes of leiomyosarcoma: Moving toward a consensus

Leiomyosarcoma (LMS) is one of the most common soft tissue sarcoma (STS) subtypes, accounting for up to 20%.

Clinically Relevant Molecular Subtypes in Leiomyosarcoma

In a previous study, our group proposed the existence of three molecular subtypes of leiomyosarcoma by using microarray-based gene expression profiling on 51 ...

Molecular Subtypes of Uterine Leiomyosarcoma and Correlation ...

Uterine leiomyosarcoma (ULMS), the most common subtype of uterine sarcoma, is a rare tumor, with an annual incidence of 0.64 per 100,000 women [1]. ULMS is ...

Molecular subtyping of leiomyosarcoma with 3′ end RNA sequencing

Abstract. Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted ...

Discovery of molecular subtypes in leiomyosarcoma through ...

Request PDF | Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling | Leiomyosarcoma (LMS) is a soft tissue tumor with a ...

Identification of three molecular subtypes in leiomyosarcoma (LMS). A

Subsequently, Guo et al. defined 3 subtypes of LMS by biologic makeup [19] . Type 1 showed smooth muscle differentiation; type 2 showed poor differentiation, ...

Therapeutic advances in leiomyosarcoma - Frontiers

Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle differentiation and is one of the most common subtypes of soft tissue sarcomas ( ...

Multiomic analysis to reveal distinct molecular profiles of uterine and ...

Background: Leiomyosarcoma (LMS) is a rare group of mesenchymal malignancies found in the uterus, retroperitoneum, skin, or other soft-tissue sites.

Clinically Relevant Molecular Subtypes in Leiomyosarcoma - OUCI

Abstract Purpose: Leiomyosarcoma is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no ...

Epigenetic signatures differentiate uterine and soft tissue ...

Leiomyosarcomas (LMS) are diverse, rare, and aggressive mesenchymal soft tissue sarcomas. Epigenetic alterations influence multiple aspects of ...

Clinically relevant molecular subtypes in leiomyosarcoma - Grantome

The current treatment of leiomyosarcoma (LMS), the most common form of sarcoma, involves ineffective systemic therapy that is based on a trial and error ...

Incidence of Sarcoma Histotypes and Molecular Subtypes in ... - PLOS

Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were ...