Mosaic Loss of Y Chromosome in White Blood Cells

Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on ...

Mosaic loss of Y chromosome (LOY) in leukocytes is the phenomenon where males lose their Y chromosome in a portion of blood cells. LOY is the most common ...

Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on ...

We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition.

Mosaic chromosome Y loss is associated with alterations in blood ...

Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes of men.

GWAS of mosaic loss of chromosome Y highlights genetic effects on ...

Mosaic loss of chromosome Y (mLOY) is characterized by the presence of cells that have lost chromosome Y. mLOY is well described in samples from ...

A polygenic risk score predicts mosaic loss of chromosome Y in ...

Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men.

Mosaic loss of Y chromosome and the association to mortality in ...

Mosaic loss of the Y chromosome (mLOY) is a common somatic mutation in the blood of elderly men and several studies have found mLOY in blood cells to be ...

Mosaic loss of the Y chromosome and men's health - Fukami - 2022

Moreover, mLOY was associated with reduced erythrocyte counts and increased counts of thrombocytes and leukocytes. It remains unknown how mLOY ...

Mosaic loss of chromosome Y promotes leukemogenesis and clonal ...

Mosaic loss of chromosome Y (mLOY) is the most frequent chromosome alteration in adult males' blood cells (1, 2). It is estimated that ...

Mosaic loss of Y chromosome in monocytes is associated with lower ...

AbstractAims. Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired mutation, increases with age, and is related to ...

Mosaic Loss of Chromosome Y in Blood Is Associated ... - Cell Press

Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is ...

Loss of Y Chromosome in White Blood Cells Leads to Heart Failure ...

“Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal ...

Chromosome Y loss and drivers of clonal hematopoiesis in ...

Since a paper published in 1963, mosaic Y chromosome loss has been recognized as a frequent event in cells of the hematopoietic system and in ...

Exploring loss of Y chromosome in white blood cells as a risk-factor ...

Leukocytes from aging males have shown a mosaic loss of chromosome Y (LOY). It is detectable in whole blood DNA from >40% - 57% of the men aged between 70-93 ...

Mosaic loss of chromosome Y in peripheral blood cells is associated ...

The mosaic loss of Y chromosome (mLOY) has been identified as a common phenomenon in multiple age-related disease (i.e., oncogenesis and ...

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and ...

Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal ...

Abstract 16532: Mosaic Loss of Y Chromosome in Leukocytes ...

Conclusion: Among patients with heart failure, LOY in blood cells is associated with increased risk of death across the complete range of ...

Men Lose Y Chromosomes as They Age - The Atlantic

In the 1960s, doctors counting the number of chromosomes in human white blood cells noticed a strange phenomenon.

Missing Y Chromosome in Mouse Blood Causes Heart Dysfunction

In a previous study, Forsberg and his colleagues had found that the loss of the Y chromosome in men's blood cells increases their chances of ...

Loss of the Y Chromosome: A Review of Molecular Mechanisms ...

mLOY is the most common chromosomal change observed in leukocytes in elderly men [11,12]. For a long time, mLOY was considered a physiological phenomenon ...

Mosaic loss of chromosome Y - DiVA portal

Studies support the hypothesis that mLOY in leukocytes may exacerbate disease processes in other organs. Thus, given the associations with several common ...