Motor stimulant effects of the adenosine A2A receptor antagonist ...

Several evidences indicate that the selective blockade of adenosine A2A receptors counteracts the motor activity impairment in experimental models of ...

Motor Stimulant Effects of the Adenosine A2A Receptor Antagonist ...

receptor agonists and antagonists, respectively, on mo- tor behavior (Ferré et al., 1997). The synthesis of selective adenosine A2A receptor antagonists has ...

Can adenosine A2A receptor antagonists modify motor behavior ...

Istradefylline administration did not alter the changes in these markers, paralleling the lack of effect in preventing l-DOPA-induced AIMs. The overall ...

Adenosine A2A receptor antagonists exert motor and ... - PubMed

Results: The selective deletion of A(2A)Rs in forebrain neurons abolished the motor stimulant effects of the A(2A)R antagonist KW-6002 but did not affect acute ...

Lack of tolerance to motor stimulant effects of a selective adenosine ...

It is well known that tolerance develops to the actions of caffeine, which acts as an antagonist on adenosine A1 and A2A receptors.

Involvement of Adenosine A1 and A2A Receptors in the Motor ...

More than a synergistic effect, our results showed evidence for and additive motor activating effect of A1 and A2A receptor antagonists. Thus, a ...

Motor stimulant effects of the adenosine A2A receptor antagonist ...

Motor stimulant effects of the adenosine A2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatments in 6‐hydroxydopamine‐lesioned rats.

A Crucial Role for Forebrain Adenosine A 2A Receptors in ... - Nature

Adenosine A2A receptors (A2ARs) are well positioned to influence the maladaptive CNS responses to repeated dopaminergic stimulation in ...

Motor stimulant effects of the adenosine A2A receptor antagonist ...

Request PDF | Motor stimulant effects of the adenosine A2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatment in ...

Adenosine A2A receptor antagonists: Potential therapeutic and ...

Adenosine A2A receptor antagonists by reversing motor impairments in animal models of PD and by contrasting cell degeneration are some of the most promising ...

Adenosine A2A receptors and depression - Neurology.org

In support of this idea, administration of the dopamine D2 receptor antagonist haloperidol prevented antidepressant-like effects elicited by SCH 58261 in the ...

Lack of tolerance to motor stimulant effects of a selective adenosine ...

It is well known that tolerance develops to the actions of caffeine, which acts as an antagonist on adenosine A(1) and A(2A) receptors.

Adenosine A1-A2A receptor heteromers - IMR Press

Lack of tolerance to motor stimulant effects of a selective adenosine A (2A) receptor antagonist. Eur J. Pharmacol 406, 345-354 (2000). 26. Popoli, P., Regio ...

A2A Adenosine Receptor Antagonism Enhances Synaptic and ...

Since D2 DA and A2A-adenosine receptors (A2A-Rs) have antagonistic effects on striatal neurons, drugs targeting adenosine receptors such as caffeine-like ...

Potential of Adenosine A2A Receptor Antagonists in the Treatment ...

Preliminary studies in humans with nonselective adenosine receptor antagonists have indicated that this motor stimulant activity may extend to a reduction ...

Adenosine A2A receptor antagonists improve deficits in initiation of ...

The results provide the first evidence that blockade of A2A receptors is effective in antagonizing specific motor deficit induced by DA neuron degeneration, ...

Motor effects induced by a blockade of adenosine A receptors in the ...

6,7 There is growing evidence to suggest that motor stimulant effects elicited by systemic administration of A2A receptor antagonists are medi- ated by a ...

Effects of the adenosine A2A receptor antagonist KW6002 on the ...

These findings suggest that. KW6002 reduces inflammation and dopaminergic neuron loss, leading to less motor symptoms in this animal model of ...

The Role of Adenosine Receptors in Psychostimulant Addiction

Nowadays, we know that adenosine, by acting on adenosine A1 and A2A receptors, is known to antagonistically modulate dopaminergic neurotransmission and ...

Adenosine A2A receptor antagonist - Wikipedia

Adenosine A2A receptor antagonists are a class of drugs that blocks adenosine at the adenosine A2A receptor. Notable adenosine A2A receptor antagonists ...