Mouse models of sarcopenia

Mouse models of sarcopenia: classification and evaluation - PMC

This paper reviews the mouse models that can be used in the study of sarcopenia, including ageing models, genetically engineered models, hindlimb suspension ...

Two Types of Mouse Models for Sarcopenia Research: Senescence ...

We discuss cases where senescence-accelerated and genetically engineered mouse models were used in sarcopenia research and different perspectives to use them.

Mouse models of accelerated aging in musculoskeletal research for ...

Mouse models of sarcopenia often involve genetically modified mice, age-induced muscle wasting, or disuse-induced muscle atrophy models (Rydell-Tormanen and ...

Animal models of sarcopenia - Aging Cell - Wiley Online Library

The use of model organisms, such as mice, rats, flies, and worms, has advanced the field of sarcopenia research by identifying therapeutic strategies and ...

Experimental Models of Sarcopenia: Bridging Molecular Mechanism ...

The most commonly used in vitro models to study the molecular aspects of skeletal muscle cells are the rat skeletal muscle L6 cells and murine C2C12 cells [77, ...

Mouse sarcopenia model reveals sex- and age-specific differences ...

Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms.

Molecular and phenotypic analysis of rodent models reveals ...

We found that rodents recapitulate mitochondrial changes observed in human sarcopenia, while inflammatory responses are conserved at pathway but not gene level.

Mouse models of sarcopenia: classification and evaluation

This paper reviews the mouse models that can be used in the study of sarcopenia, including ageing models, genetically engineered models, hindlimb suspension ...

Murine models of atrophy, cachexia, and sarcopenia in skeletal ...

This review evaluates several murine models that have the potential to elucidate biochemical processes integral to sarcopenia.

Sarcopenia phenotype and impaired muscle function in male mice ...

Sarcopenia differs from usual muscle atrophy in that it is closely related to fiber-type shifts. This was one of our strong motivations to ...

Preclinical assessment of rodent jumping power with a novel ...

Generally, animal models, particularly rodents, are commonly used to study the pathophysiology of sarcopenia and consequent potential test ...

Caloric Restriction Combined with Immobilization as Translational ...

Here, we investigated the translational value of three potential mouse models for sarcopenia, namely partial immobilized (to mimic sedentary lifestyle), caloric ...

(PDF) Two Types of Mouse Models for Sarcopenia Research

Mouse models are still the most useful ones for determining mechanisms underlying sarcopenia through correlations and interventions involving specific genes and ...

Molecular changes in transcription and metabolic pathways ...

We measured the time course for development of reduced muscle mass in the Sod1−/− sarcopenia mouse model. ... mice and other denervation models ( ...

Rodent Model of Muscular Atrophy for Sarcopenia Study

Rodent model of muscular atrophy for sarcopenia study. Article information: J Bone Metab. 2020;27(2):97-110. Publication date (electronic) : 2020 May 31.

Muscle mass, structural and functional investigations of senescence ...

Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia ...

and age-specific differences revealed by mouse sarcopenia models

In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant ...

Non-invasive muscle contraction assay to study rodent models of ...

The need for therapies to treat age-related sarcopenia has attracted intensive preclinical research. To facilitate the discovery of these ...

Decoding the decline: unveiling drivers of sarcopenia - JCI

A mouse model facilitates a clinically relevant definition for sarcopenia and reveals age-related and molecular changes underlying decreased muscle mass and ...

Mouse Model of Sarcopenia - Synapse.org

'Mouse Model of Sarcopenia' (Synapse ID: syn4589) is a folder on Synapse. Synapse is a platform for supporting scientific collaborations centered around ...