Multiple|Tissue Integrative Transcriptome|Wide Association Studies ...

Multiple-Tissue Integrative Transcriptome-Wide Association Studies ...

Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, ...

Transcriptome-wide association studies: recent advances in ... - Nature

(1) Training stage: this step aims to estimate regulatory effect sizes of multiple SNPs on the gene expression level by fitting a multivariate ...

Multi-tissue transcriptome-wide association study identifies eight ...

Genome-wide association studies (GWAS) have revealed sixteen risk loci for endoemtrial cancer but the identification of candidate ...

Article Subset-based method for cross-tissue transcriptome-wide ...

... tissue transcriptome-wide association studies improves ... Wright, et al. Integrative approaches for large-scale transcriptome-wide association studies.

Expression- and splicing-based multi-tissue transcriptome-wide ...

Although several transcriptome-wide association studies (TWASs) have been performed to identify genes associated with overall breast cancer ...

Multi-tissue transcriptome-wide association study identifies novel ...

Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. (2016) 48:245–52. doi: 10.1038/ng.3506. PubMed ...

Subset-based method for cross-tissue transcriptome-wide ...

Integrating results from genome-wide association studies (GWASs) and studies of molecular phenotypes such as gene expressions can improve our understanding ...

scTWAS Atlas: an integrative knowledgebase of single-cell ...

Abstract. Single-cell transcriptome-wide association studies (scTWAS) is a new method for conducting TWAS analysis at the cellular level to ...

a systematic literature review of transcriptome-wide association ...

This is accomplished by combining genome-wide association study (GWAS) data and tissue-specific gene expression profiles [3]. GWAS is a research ...

A multi-tissue, splicing-based joint transcriptome-wide association ...

transcriptome-wide association studies · breast cancer · intron excision · multi-tissue ... 20. Cotto, K.C. ∙ Feng, Y.Y. ∙ Ramu, A. ... Integrated analysis of ...

A tissue-specific collaborative mixed model for jointly analyzing ...

Abstract. Transcriptome-wide association studies (TWASs) integrate expression quantitative trait loci (eQTLs) studies with genome-wide association studies.

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide ... - PLOS

... gene expression and TWAS power to detect gene-trait associations. This integrative approach to transcriptome-wide imputation and association studies aids in ...

A joint transcriptome-wide association study across multiple tissues ...

In fact, transcriptome-wide association studies (TWASs) of breast cancer performed using gene expression prediction models trained in breast tissue have yet to ...

Transcriptome wide association studies: general framework and ...

... Integrative approaches for large-scale transcriptome-wide association studies. ... tissue context on gene prioritization for predicted transcriptome-wide ...

Multi-tissue polygenic models for transcriptome-wide association ...

A fundamental barrier to interpreting the role of non-coding genetic variation identified by genome-wide association studies (GWAS) is ...

Integrative eQTL-weighted hierarchical Cox models for SNP-set ...

Xiao L, Yuan Z, Jin S, Wang T, Huang S, Zeng P. Multiple-tissue integrative transcriptome-wide association studies discovered new genes ...

Multi-tissue transcriptome-wide association studies - ResearchGate

PDF | Many genetic mutations affecting phenotypes are presumed to do so via altering gene expression in particular cells or tissues, ...

Multi‐tissue transcriptome‐wide association studies - ResearchGate

PDF | A transcriptome‐wide association study (TWAS) attempts to identify disease associated genes by imputing gene expression into a genome‐wide.

Multi-tissue transcriptome-wide association studies - bioRxiv

Abstract. Many genetic mutations affecting phenotypes are presumed to do so via altering gene expression in particular cells or tissues, ...

Transcriptome wide association studies: general framework and ...

In particular, GTEx provides the most comprehensive database, with adequate power to predict gene expression in 54 tissue sites (The number is ...