Multiple Functions of BCL|2 Family Proteins
Multiple Functions of BCL-2 Family Proteins - PMC - PubMed Central
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers ...
Multiple functions of BCL-2 family proteins - PubMed
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes ...
The role of BCL-2 family proteins in regulating apoptosis and cancer ...
Studies have shown that mutations in the BCL-2 and BAX proteins are frequently detected in several types of cancers, suggesting that they play crucial roles in ...
Multiple Functions of BCL-2 Family Proteins
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers ...
BCL-2 family proteins: changing partners in the dance towards death
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP).
Multiple Functions of BCL-2 Family Proteins - University of Rochester
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers ...
Multiple functions of BCL-2 family proteins - Johns Hopkins University
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers ...
Protein Bcl 2 - an overview | ScienceDirect Topics
Members of the proto-oncogene family that includes Bcl-2-like proteins are involved in the control of apoptosis in a range of different cell types33,34. Bcl-2 ...
Non-apoptotic functions of BCL-2 family proteins - Nature
Several key pieces of data support distinct roles for BCL-2, BCL-XL, and MCL-1 at the inner mitochondrial membranes (IMMs) (Figure 3, right ...
Bcl-2 Family - an overview | ScienceDirect Topics
The second member of the Bcl-2 family to be discovered was Bax. This protein was found during a yeast two-hybrid search for proteins that interact with Bcl-2 ( ...
The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most ...
Bcl-2 family proteins: master regulators of cell survival - De Gruyter
The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of ...
Role of Bcl‐2 family proteins in apoptosis: apoptosomes or ...
The Bcl-2 family is the best characterized protein family involved in the regulation of apoptotic cell death, consisting of anti-apoptotic and pro-apoptotic ...
Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 ...
Given the evidenced multiple functions of BH4 domain of Bcl-2 family proteins described so far, there has been a growing interest in ...
Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins
In fact, proper subcellular targeting and distribution are critical for the function of intracellular proteins. B-cell lymphoma 2 (Bcl-2) family ...
BCL-2 protein family: attractive targets for cancer therapy | Apoptosis
Several proteins participate in the process of programmed cell death, including caspases (cysteinyl aspartate-specific proteases), their ...
Bcl-2–family proteins and hematologic malignancies
In fact, the antiapoptotic function of Bcl-2 was first elucidated in gene transfection studies, where interleukin-3–dependent murine ...
Expanding roles of BCL-2 proteins in apoptosis execution and beyond
The proteins of the BCL-2 family are known as key regulators of apoptosis, with interactions between family members determining ...
Ancient and conserved functional interplay between Bcl-2 family ...
In metazoans, Bcl-2 family proteins are major regulators of mitochondrially mediated apoptosis; however, their evolution remains poorly understood.
Dysregulation of BCL-2 family proteins in blood neoplasm
As the name implies, these proteins possess one or two of the four BCL-2 homology domains (BH1–BH4). According to their roles, they are classified as pro- ...