Multivariate genome|wide analysis of aging|related traits identifies ...

Multivariate genome-wide analysis of aging-related traits identifies ...

mvAge (effective n = ~1.9 million participants of European ancestry) identified 52 independent variants in 38 genomic loci. Twenty variants were novel.

Multivariate genome-wide analysis of aging-related traits identifies ...

The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, extreme longevity, frailty and epigenetic aging, ...

Multivariate genome-wide analysis of aging-related traits identifies ...

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Multivariate genome-wide analysis of aging-related traits identifies ...

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging · Fingerprint · Projects (1) ...

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging. Rosoff DB, et al. Nat Aging. 2023 ...

Mendelian randomization of genetically independent aging ... - Nature

In the present study, we combine six European-ancestry genome-wide association studies of human aging traits—healthspan, father and mother ...

aging - GWAS Catalog

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Multivariate genome-wide analysis of aging-related traits identifies ...

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging ... Authors: Daniel B. Rosoff; Lucas A.

Multivariate genomic scan implicates novel loci and haem ...

Ageing phenotypes are of great interest but are difficult to study genetically, partly due to the sample sizes required. Here, the authors ...

Multivariate genome-wide association study of rapid automatised ...

For a phenotype to be considered an endophenotype for a complex trait disorder, it must have a genetic component, be independent of clinical state (affected or ...

Multivariate genome-wide analyses of the well-being spectrum

We performed a lookup for the genome-wide-significant loci reported in published studies of related traits. We identified 26 loci in proximity (< 250 kb) to the ...

Genome-wide association studies identify 137 genetic loci for DNA ...

Overall, this study highlights the shared genetic architecture between epigenetic aging, lifestyle factors (smoking, obesity), and parental ...

Complimentary Methods for Multivariate Genome-Wide Association ...

This approach identifies two known and one novel loci. In the second multivariate method, we applied principal component analysis (PCA) to the ...

Multivariate Genome-wide Association Analysis of a Cytokine ...

Here, we aimed to identify and characterize genetic variants with pleiotropic effects on cytokines. Using three population-based cohorts (n = 9,263), we ...

Multivariate genomic analysis of 1.5 million people identifies genes ...

We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses.

Vertex-wise multivariate genome-wide association study identifies ...

GWAS is a powerful tool for identifying genetic variants that shape the human cortex, but the full breadth of reported heritability estimates ...

Multivariate aging GWAS modeled with genomic SEM a, Genetic...

... age-related GWASs not explained by the mvAge common factor. Source data from publication: Multivariate genome-wide analysis of aging-related traits identifies ...

Multivariate genomic analysis of 1.5 million people identifies genes ...

We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By ...

Multivariate genome-wide association analysis by iterative hard ...

In a genome-wide association study, analyzing multiple correlated traits simultaneously is potentially superior to analyzing the traits one by one. Standard ...

Multivariate genome wide association and network analysis of ...

Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in ...