Muscle|specific ER|associated degradation maintains ...

Muscle-specific ER-associated degradation maintains postnatal ...

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is ...

Muscle-specific ER-associated degradation maintains ... - JCI Insight

In this study, we show that skeletal myocyte–specific SEL1L-HRD1 ERAD is essential for maintaining muscle mass and whole-body energy metabolism in young ...

Muscle-specific ER-associated degradation maintains postnatal ...

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.

Muscle-specific ER-associated degradation maintains ... - JCI Insight

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism ... Citation Information: JCI ...

[PDF] Muscle-specific ER-associated degradation maintains ...

It is reported that the SEL1L-HRD1 ER-associated degradation (ERAD) complex, the primary molecular machinery that degrades misfolded proteins in the ER, ...

(PDF) Muscle specific ER-associated degradation maintains ...

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Muscle-specific ER-associated degradation maintains postnatal ...

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism. Benedict Abdon, Yusheng Liang, Débora da Luz ...

Qi, Ling - Center for Membrane and Cell Physiology

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism. JCI INSIGHT, 8(17). doi:10.1172/jci.insight ...

Proteomic screens of SEL1L-HRD1 ER-associated degradation ...

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism. JCI Insight 8, e170387 ...

Muscle-specific ER-associated degradation maintains postnatal ...

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism. Abdon, B.; Liang, Y.; da Luz Scheffer, ...

Unraveling the roles of endoplasmic reticulum-associated ... - Frontiers

Mice specific deletion of Sel1L in POMC ... Sel1L-Hrd1 ER-associated degradation maintains beta cell identity via TGF-beta signaling.

ER-associated degradation adapter Sel1L is required for CD8+ T ...

Mice were bred and maintained in specific pathogen-free animal facility (22°C with 40% humidity) on a 12-h dark/12-h light cycle at the University of Michigan.

ER-associated degradation in health and disease – from substrate ...

ERAD may function in a constitutive capacity to maintain optimal levels of key proteins regulating critical physiological process such as food ...

Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic ...

Xu et al., Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche ...

ER-associated degradation: Protein quality control and beyond

Despite these differences, both US2 and US11 act as adaptors to deliver a specific ERAD substrate, MHC I heavy chain, to the E3 ligase complexes ...

Muscle-specific ER-associated degradation maintains postnatal ...

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism. Journal: JCI Insight.

Genome-wide CRISPR Analysis Identifies Substrate-Specific ...

Proteins that fail to fold or assemble correctly in the ER are degraded by cytoplasmic proteasomes via a process known as ER-associated ...

Sel1L is indispensable for mammalian endoplasmic reticulum ...

... specific manner. ... Q Wang, et al., A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via ...

Here, we performed a side-by-side comparison of mice carrying β cell-specific deletion of ER-associated degradation (ERAD) and autophagy. We reported that ...

A cross-kingdom conserved ER-phagy receptor maintains ... - eLife

These autophagic flux assays further demonstrated ER-stress-specific autophagic degradation of AtC53 and HsC53 (Figure 3). Figure 2 with 3 ...