Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling

Overexpression of PGC-1α via transgene and in vivo DNA transfection has been found to be effective in ameliorating mitostasis and reduces IM-induced muscle ...

Thus, the purpose of this article is to review the accumulated research evidence that muscle atrophy may be caused by the discord of intracellular signaling, ...

Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling

Redox Signal. 33, 727–744. Keywords: atrophy, mitochondria, PGC-1a, proteolysis, redox signaling, skeletal muscle. Introduction.

Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling

The phenotypic outcome of the discord of mitochondrial homeostasis is elevated proteolysis and muscle atrophy. The demonstration that PGC-1α overexpression via ...

Muscle Disuse Atrophy

Muscle immobilization causes discord of cellular signaling played by mTOR, FoxO, NFκB, AMPK and mitochondria.

Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling ...

Significance: Regular contractile activity plays a critical role in maintaining skeletal muscle morphological integrity and physiological function.

Intracellular signaling during skeletal muscle atrophy

This review focuses on the most recent findings related to intracellular signaling during muscle atrophy involving muscle ubiquitin ligases, ...

Mitochondrial dysregulation and muscle disuse atrophy - PMC

Crosstalk of signaling pathways during muscle atrophy ... There is strong evidence that alteration of mitochondrial morphological changes due to ...

[PDF] Mitochondrial dysregulation and muscle disuse atrophy

Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling. L. JiDongwook YeoChounghun Kang. Medicine, Biology. Antioxidants & redox signaling. 2020.

Ubiquitin-proteasome pathway in skeletal muscle atrophy - Frontiers

Under catabolic conditions, protein degradation surpasses synthesis, leading to muscle weakness and atrophy. Conditions such as disuse, sarcopenia, cancer- ...

The molecular basis of skeletal muscle atrophy

Also, it is now apparent that the transcription factor NF-κB is a key intracellular signal transducer in disuse atrophy. Transcriptional profiles of atrophying ...

Signaling mechanisms involved in disuse muscle atrophy

Collectively, the disuse-induced muscle atrophy is a highly ordered process that is controlled by interactions between intracellular signaling pathways rather ...

Forkhead Box O Signaling Pathway in Skeletal Muscle Atrophy

Skeletal muscle atrophy is the consequence of protein degradation exceeding protein synthesis because of disease, aging, and physical inactivity.

(PDF) Cellular Mechanism of Immobilization-induced Muscle Atrophy

However, when muscles stop contraction, such as during immobilization (IM) and denervation, withdrawal of IGF/Akt/mTOR signaling allows FoxO- ...

Signaling in Muscle Atrophy and Hypertrophy | Physiology

Furthermore, IGF1 transgenic mice are resistant to muscle atrophy induced either by angiotensin treatment or in a mouse model of cardiac cachexia (88, 91), and ...

Type 2 diabetes mellitus related sarcopenia: a type of muscle loss ...

The decrease in muscle protein synthesis caused by disuse muscle atrophy leads to the reduction in muscle mass and strength. However, this can be restored ...

What signaling pathways are involved in controlling muscle atrophy ...

... Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling. 5. Muscle atrophy during limb immobilization is caused by suppressing the IGF/Akt/mTOR ...

Li Li Ji - School of Kinesiology - University of Minnesota

Muscle Disuse Atrophy Caused by Discord of intracellular Signaling. Antioxid.& Redox Signal. 727-744, 2020. doi: 10.1089/ars.2020.8072. Ji, L. L., D. Yeo ...

https://f1000research.com/articles/8-1621/v1/xml

The phenotypic outcome of the discord of mitochondrial homeostasis is elevated proteolysis and muscle atrophy. ... In the case of muscle disuse atrophy, FoxO3 is ...

The effect of 8 weeks of resistance training on muscle function and ...

Muscle disuse atrophy caused by discord of intracellular signaling. ... ROS and nNOS in the regulation of disuse-induced skeletal muscle atrophy. The ...