Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in ...

Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in ... - PubMed

Purpose: Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) ...

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in multiple tumors, including approximately 20% of AMLs. ... Mutant IDH1/2 (mIDH1/2) ...

Ivosidenib in Isocitrate Dehydrogenase 1 - Mutated Advanced Glioma

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in most LGGs (> 70%). Ivosidenib is an inhibitor of mutant IDH1 (mIDH1) under ...

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ...

Resistance to ivosidenib due to a second site mutation of IDH1 R132C, leading to IDH1 R132C/S280F, has emerged. We describe biochemical, ...

Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia

Somatic mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) occur in 6 to 10% of patients with acute myeloid leukemia. Mutant IDH1 ...

Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma - Nature

Ivosidenib in isocitrate dehydrogenase 1-mutated advanced glioma. J ... Phase I study of the mutant IDH1 inhibitor ivosidenib: safety ...

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 ...

Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) ...

FDA Approval Summary: Ivosidenib for Relapsed or Refractory ...

Ivosidenib showed no inhibition of IDH2 mutant or IDH2WT enzymes at concentrations >100 μmol/L. In vitro studies in cell lines expressing IDH1 mutations showed ...

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer ...

In the most common IDH1/2 mutants, the wild-type IDH function of oxidative decarboxylation of isocitrate to α-ketoglutarate is lost due to mutation of critical ...

Clinical Trials Using Ivosidenib - NCI

Change (mutation) in the FLT3 gene can cause tumor cells to grow, and mutations in either the IDH1 or IDH2 genes can cause low blood cell counts. Gilteritinib ...

Isocitrate dehydrogenase-1 (IDH1) inhibitors | DrugBank Online

Ivosidenib, An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.

Olutasidenib: from bench to bedside | Blood Advances

Isocitrate dehydrogenase 1 (IDH1) mutations are recurrently mutated in about 10% of patients with acute myeloid leukemia (AML). ... IDH1mut in AML ...

Isocitrate Dehydrogenase-1 Inhibitors | DrugBank Online

Ivosidenib, An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.

Olutasidenib and Ivosidenib for Treatment of mIDH1 Acute Myeloid ...

Mutations in isocitrate dehydrogenase-1 (IDH1) are recurrent in several malignancies and prevalent in acute myeloid leukemia (AML).

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or ...

... mutations treated with the targeted mutant IDH1 inhibitor, AG-120. ... mutant isocitrate dehydrogenase 2: analysis of a phase 1/2 study.

Mutant Isocitrate Dehydrogenase (mIDH) Inhibitors, Enasidenib or ...

Mutant Isocitrate Dehydrogenase (mIDH) Inhibitors, Enasidenib or Ivosidenib, in Combination with Azacitidine (AZA): Preliminary Results of a ...

Mutant isocitrate dehydrogenase 1 inhibitor ivosidenib in ...

PURPOSE: Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant ...

Ivosidenib - an overview | ScienceDirect Topics

Ivosidenib is a reversible inhibitor of the mutant IDH1 enzyme. The most common of such mutations are R132H and R132C substitutions. Ivosidenib selectively ...

(PDF) Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in ...

(C) Heat map showing baseline co-occurring mutations identified by variant type and patient characteristics (mutant IDH1 clearance by BEAMing ( ...

Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in ...

Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of -mutant (m ) acute myeloid leukemia (AML).

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