Mutation Signatures Depend on Epigenomic Contexts

Mutation Signatures Depend on Epigenomic Contexts - PubMed

Mutation signatures - the patterns of acquired genetic changes in somatic genomes - provide critical insights into DNA repair defects and exposure to ...

Mutation Signatures Depend on Epigenomic Contexts - Cell Press

Since chromatin and epigenomic contexts influence DNA damage and repair pathway choices, taking both epigenomic and sequence contexts of the ...

Mutation Signatures Depend on Epigenomic Contexts - ScienceDirect

Forum. Mutation Signatures Depend on Epigenomic Contexts ... Mutation signatures – the patterns of acquired genetic changes in somatic genomes – provide critical ...

Mutation Signatures Depend on Epigenomic Contexts - Cell Press

Genome-wide Mutation Patterns Depend on Epigenomic Contexts. (A) Computational deconvolution of mutation patterns from cancer genomes identifies a number of ...

Mutation Signatures Depend on Epigenomic Contexts. - Europe PMC

Since chromatin and epigenomic contexts influence DNA damage and repair pathway choices, taking both epigenomic and sequence contexts of the mutations into ...

Mutation Signatures Depend on Epigenomic Contexts.

Semantic Scholar extracted view of "Mutation Signatures Depend on Epigenomic Contexts." by Neil Coleman et al.

Characteristics of mutational signatures of unknown etiology - PMC

Previous works on mutational landscape of tumor genomes and mutational signatures have primarily analyzed epigenomic contexts from closely ...

Mutation Signatures Depend on Epigenomic Contexts - ResearchGate

Since chromatin and epigenomic contexts influence DNA damage and repair pathway choices, taking both epigenomic and sequence contexts of the mutations into ...

Mutation Signatures Depend on Epigenomic Contexts – Fingerprint ...

Keyphrases · Mutation Signature · Epigenomics · Etiology · In Cancer · Aging · Sequence Context · DNA Repair Defect · Somatic Genome ...

Mutational Signatures of Replication Timing and Epigenetic ...

... signatures that do not depend on which functional compartments the spectra are ascertained from. ... mutation rates in the same genomic sequence contexts.

Mutational signature SBS8 predominantly arises due to late ...

Analyzing somatic mutation data from multiple cancer types in their epigenomic contexts, we show that SBS8 preferentially occurs in gene-poor, ...

Mutation Signatures Depend on Epigenomic Contexts - Academia.edu

These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational ...

Epigenetic signatures in cancer: proper controls, current challenges ...

Examples include mutations of the de novo DNA methyltransferase 3a (DNMT3A). DNMT3A was reported to be mutated in AML patients, and these ...

Computational approaches for identifying epigenomic contexts of ...

... mutation signatures have been identified based on local sequence contexts to address this need. But, mechanisms of DNA damage and repair preferences depend ...

Mining mutation contexts across the cancer genome to map tumor ...

The epigenome data were obtained from the ENCODE and the Epigenome Roadmap Study. Each epigenomic meta-feature listed in (iv) and (v) was ...

Mutational signatures associated with exposure to carcinogenic ...

When epigenomic contexts were taken into consideration, we found that mutations ... S. Mutation signatures depend on epigenomic contexts . Trends ...

Whole-Genome and Epigenomic Landscapes of Etiologically ...

This is because, in general, TFs can act as either activators or repressors depending on the regulatory context. Consequently, one cannot in general predict ...

Epigenomic mutation - EurekaMag

2018: Mutation Signatures Depend on Epigenomic Contexts Trends in Cancer 4(10): 659-661 · Wilson, S.; Filipp, F.Volker. 2018: A network of epigenomic and ...

Mutational signature decomposition with deep neural networks ...

Since this procedure depends on the number of samples available and the variability between samples, the definition of mutational signatures ...

MutationalPatterns: the one stop shop for the analysis of mutational ...

This updated package supports stricter signature refitting on known signatures in order to prevent overfitting. Using simulated mutation ...