Mutational signature SBS8 predominantly arises due to late ...

Although a majority of somatic mutations in cancer are passengers, their mutational signatures provide mechanistic insights into mutagenesis ...

[PDF] Mutational signature SBS8 predominantly arises due to late ...

Analyzing somatic mutation data from multiple cancer types in their epigenomic contexts, it is shown that SBS8 preferentially occurs in ...

(PDF) Mutational signature SBS8 predominantly arises due to late ...

Analyzing somatic mutation data from multiple cancer types in their epigenomic contexts, we show that SBS8 preferentially occurs in gene-poor, ...

Characteristics of mutational signatures of unknown etiology - PMC

Singh et al. used an hidden Markov model (HMM)-based approach to identify different mutagenesis-related composite epigenomic contexts, and then ...

Mutational signatures association with replication timing in normal ...

The two ubiquitous signatures, SBS1 and SBS5, showed late and early bias, respectively, across multiple tissues and in mutations representing ...

Schematic representation showing emerging characteristics of SBS8...

Download scientific diagram | Schematic representation showing emerging characteristics of SBS8 mutational signature a SBS8 is suspected to arise due to ...

Cancer Mutational Processes Vary in Their Association with ...

Distinctive patterns of somatic mutation accumulation, termed mutational signatures, are indicative of processes sustained within tumors.

Mutation Signatures Depend on Epigenomic Contexts - ScienceDirect

Mutation signatures – the patterns of acquired genetic changes ... Mutational signature SBS8 predominantly arises due to late replication errors in cancer.

[PDF] Looking beyond drivers and passengers in cancer genome ...

Mutational signature SBS8 predominantly arises due to late replication errors in cancer · Biology, Medicine. Communications Biology · 2020.

Cell-type specificity of the human mutation landscape with respect to ...

27. Singh, V.K. ∙ Rastogi, A. ∙ Hu, X. ... Mutational signature SBS8 predominantly arises due to late replication errors in cancer. Commun ...

SBS8 - Mutational Signatures - COSMIC

Mutational signatures exhibit asymmetric number of mutations due to either one of the DNA strands being preferentially repaired or one of the DNA strands ...

Mutation Signatures Depend on Epigenomic Contexts. - Europe PMC

Mutational signature SBS8 predominantly arises due to late replication errors in cancer. Singh VK, Rastogi A, Hu X, Wang Y, De S · Commun Biol, 3(1):421, 03 ...

Mutational signature distribution varies with DNA replication timing ...

Mutational signature SBS8 predominantly arises due to late replication errors in cancer. ... Articles in the Open Access Subset are available under a Creative ...

Signatures Beyond Oncogenic Mutations in Cell-Free DNA ...

Mutational Signature SBS8 Predominantly Arises Due to Late Replication Errors in Cancer. Commun. Biol. 3, 421. doi:10.1038/s42003-020-01119-5. PubMed ...

Comprehensive analysis of mutational signatures in pediatric cancers

Mutational signature SBS8 predominantly arises due to late. 522 replication errors in cancer. Commun Biol 3, 421 (2020). 523. 25. Voronina, N ...

Mutational signatures associated with exposure to carcinogenic ...

Y. ,. De. S. Mutational signature SBS8 predominantly arises due to late replication errors in cancer . Commun.

Mutational signatures among young-onset testicular cancers

Mutational signatures are distinct patterns of somatic mutations that arise ... Mutational signature SBS8 predominantly arises due to late ...

Topography of mutational signatures in human cancer - ScienceDirect

Somatic mutations due to signatures SBS2 and SBS13, both attributed to the aberrant behavior of the APOBEC3 family of deaminases, were found ...

Cancer Mutational Processes Vary in Their Association with ... - OUCI

... late replicating regions using sequence context normalization and chromatin data ... Singh, Mutational signature SBS8 predominantly arises due to late ...

Biostatistics - Research Accomplishments - Rutgers Cancer Institute

Mutational signature SBS8 predominantly arises due to late replication errors in cancer. Commun Biol. 2020 AUG 03; 3(1):421. DOI: 10.1038/s42003-020-01119-5 ...