Mutations associated with progression in follicular lymphoma predict ...

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303

Follicular lymphoma (FL) is clinically heterogeneous, with select patients tolerating extended watch-and-wait, whereas others require prompt ...

Mutations associated with progression in follicular lymphoma predict ...

The 2 most commonly mutated genes in FL were CREBBP (58.8%) and KMT2D (57.0%), with mutations in EZH2 (18.3%) and EP300 (13.3%) occurring less frequently.

Mutations Associated with Progression in Follicular Lymphoma ...

Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes in Newly Diagnosed Patients (Alliance 151303). David A ...

Mutations associated with progression in follicular lymphoma predict ...

MAP (CREBBP, STAT6, TP53, IGLL5, B2M, SOCS1, and MYD88) confer adverse risk when found at FL diagnosis.•Low-risk m7-FLIPI is predictive of prolonged ...

Mutations associated with progression in follicular lymphoma predict ...

Nonetheless, mutation burden in dx FL was not associated with frontline progression-free survival (PFS). CREBBP was the only gene more commonly ...

"Mutations associated with progression in follicular lymphoma ...

Follicular lymphoma (FL) is clinically heterogeneous, with select patients tolerating extended watch-and-wait, whereas others require prompt ...

Mutations Associated with Progression in Follicular Lymphoma ...

Nonetheless, mutation burden in dx FL was not associated with frontline progression-free survival (PFS). CREBBP was the only gene more commonly mutated in FL ...

Predicting early progression in follicular lymphoma - Liu

In the PRIMA study, EZH2 mutations or gains were found in 37% of samples analyzed, which was demonstrated to be associated with a favorable PFS. In terms of ...

Multi-omics profiling of longitudinal samples reveals early genomic ...

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Adv. 2023;7 ...

Mutations in early follicular lymphoma progenitors are associated ...

These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By ...

Molecular Biomarkers in Prediction of High-Grade Transformation ...

Follicular lymphoma (FL) represents the most common indolent lymphoma subtype. The malignant cells arise from B cells, which have often acquired a t(14;18) BCL2 ...

Identification of genetic subtypes in follicular lymphoma - Nature

KMT2D (63.4%) and CREBBP (57.5%) represented the most frequently mutated genes, followed by TNFRSF14 (34.4%), BCL2 (32.7%), EZH2 (20.6%), FOXO1 ...

A gene-expression profiling score for prediction of outcome in ...

Genes with high correlation (>0·75) were included in an L2-penalised Cox model adjusted on rituximab maintenance to build a predictive score for progression- ...

Plasma Concentrations and Cancer-Associated Mutations in Cell ...

Follicular lymphoma (FL) is the second most frequent non-Hodgkin lymphoma accounting for 10-20% of all lymphomas in western countries. As a ...

Generation and External Validation of a Histologic Transformation ...

The clinicogenetic nomogram included the mutational status of 3 genes (HIST1HE1, KMT2D, and TNFSR14) and high-risk Follicular Lymphoma International Prognostic ...

Generation and External Validation of a Histologic Transformation ...

Follicular lymphoma (FL) is the most frequent indolent lymphoma. Some patients (10%-15%) experience histologic transformation (HT) to a more aggressive ...

Molecular Pathogenesis of Follicular Lymphoma: From Genetics to ...

Genomic alterations in genes encoding proteins in the BCR/NF-κB signaling pathway (CARD11, TNFAIP3, CD79A, CD79B, and MYD88) are present in approximately 30% of ...

Mutations Associated with Progression in Follicular Lymphoma ...

Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes in Newly Diagnosed Patients (Alliance 151303)-article.

The genetic basis of transformation and progression in follicular ...

In addition, we identified discrete gene mutations that are associated with early progression and transformation, and uncovered that a subset of TFLs (16%) have ...