NK cell survival mediated through the regulatory synapse ...

NK cell survival mediated through the regulatory synapse ... - PubMed

DCs activate NK cells during innate immune responses to viral infections. However, the composition and kinetics of the immunological synapse mediating this ...

NK cell survival mediated through the regulatory synapse with ...

Our data suggest that the regulatory synapse between NK cells and DCs limits optimal NK cell activation to areas of close DC/NK cell encounter ...

NK cell survival mediated through the regulatory synapse with ... - JCI

Blocking of IL-15Rα increased NK cell apoptosis and diminished NK cell survival during their interaction with DCs.

NK cell survival mediated through the regulatory synapse with ... - JCI

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα ... Citation Information: J Clin Invest. 2007;117(11): ...

Multiple distinct NK-cell synapses | Blood - ASH Publications

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. ,. J Clin Invest. ,. 2007. , vol. 117. 11. (pg.

The Molecular Mechanism of Natural Killer Cells Function and Its ...

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. ... death receptor-mediated apoptosis in the rejection of tumors by ...

Termination of the Activating NK Cell Immunological Synapse Is an ...

... in regulating the actin dynamics in NK cells. ... Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition.

Natural Killer cells at the frontline in the fight against cancer

... NK cell viability and improve rituximab-mediated NK cells ADCC [189]. ... NK cell immunological synapse is an active and regulated process ...

Natural Killer Cells: Development, Maturation, and Clinical Utilization

... regulated process mediated by a variety of transcriptional regulators in NK cells. Many of these transcription factors, such as T-bet, are lineage defining ...

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

Actomyosin – regulation of NKIS (NK cell immune synapse) in effector and target cells ... regulating actomyosin-mediated contractility in NK cells. Indeed ...

Regulatory NK-Cell Functions in Inflammation and Autoimmunity

(2007) NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. J. Clin. Invest. 117:3316–29. Article ...

Inability of granule polarization by NK cells defines tumor resistance ...

... (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation. ... in signaling in the natural killer cell immunological synapse.

NK cell survival mediated through the regulatory synapse ... - Altmetric

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα. Published in. Journal of Clinical Investigation, October 2007. DOI ...

Failed CTL/NK cell killing and cytokine hypersecretion are directly ...

4 B), confirming that the CTLs continued to degranulate when in synapse with an apoptosis-resistant target cell. Cytokine secretion by mouse NK ...

Reciprocal regulation of human natural killer cells and macrophages ...

The purity of isolated NK cells was 98% as determined by being CD56+ and CD3− by flow cytometry, and viability was confirmed by cells being ...

Natural killer cell immune synapse formation and cytotoxicity are ...

... mediated and sustained by actin polymerisation at the cell periphery. ... Overall, our data establish the importance of target stiffness in regulating NK cell ...

[PDF] NK cell activation by dendritic cells (DCs) requires the ...

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. · Biology, Medicine. The Journal of clinical investigation · 2007.

The Lytic NK Cell Immunological Synapse and Sequential Steps in ...

Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host defense. They are best known for their ability to mediate ...

Regulation of natural killer cell activity by glucocorticoids, serotonin ...

For this interaction, cellular communication is key. This communication is mediated by direct cellular contacts (e.g., synapse formation ...

CD56 at the human NK cell lytic immunological synapse - bioRxiv

CD56 is the main identifying cell surface molecule of NK cells and has been recently identified as a regulator of cytotoxic function in NK cell lines.