NK cell survival mediated through the regulatory synapse with ...

NK cell survival mediated through the regulatory synapse ... - PubMed

DCs activate NK cells during innate immune responses to viral infections. However, the composition and kinetics of the immunological synapse mediating this ...

Our data suggest that the regulatory synapse between NK cells and DCs limits optimal NK cell activation to areas of close DC/NK cell encounter ...

NK cell survival mediated through the regulatory synapse with ... - JCI

Blocking of IL-15Rα increased NK cell apoptosis and diminished NK cell survival during their interaction with DCs.

NK cell survival mediated through the regulatory synapse with ... - JCI

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα ... Citation Information: J Clin Invest. 2007;117(11): ...

Multiple distinct NK-cell synapses | Blood - ASH Publications

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. ,. J Clin Invest. ,. 2007. , vol. 117. 11. (pg.

The Molecular Mechanism of Natural Killer Cells Function and Its ...

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. ... death receptor-mediated apoptosis in the rejection of tumors by ...

Natural Killer cells at the frontline in the fight against cancer

... NK cell viability and improve rituximab-mediated NK cells ADCC [189]. ... NK cell immunological synapse is an active and regulated process ...

All About (NK Cell-Mediated) Death in Two Acts and an ... - Frontiers

Here we will review and discuss the available experimental evidence on how NK cells kill target cells, with a special focus on the different cell death ...

[PDF] NK cell activation by dendritic cells (DCs) requires the ...

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. · Biology, Medicine. The Journal of clinical investigation · 2007.

Regulatory NK-Cell Functions in Inflammation and Autoimmunity

(2007) NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. J. Clin. Invest. 117:3316–29. Article ...

Termination of the Activating NK Cell Immunological Synapse Is an ...

... in regulating the actin dynamics in NK cells. ... Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition.

NK cell survival mediated through the regulatory synapse ... - Altmetric

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα. Published in. Journal of Clinical Investigation, October 2007. DOI ...

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

Actomyosin – regulation of NKIS (NK cell immune synapse) in effector and target cells ... regulating actomyosin-mediated contractility in NK cells. Indeed ...

Functions of natural killer cells | Nature Immunology

Recent research highlights the fact that NK cells are also regulatory cells engaged in reciprocal interactions with dendritic cells, macrophages ...

Inability of granule polarization by NK cells defines tumor resistance ...

... (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation. ... in signaling in the natural killer cell immunological synapse.

Failed CTL/NK cell killing and cytokine hypersecretion are directly ...

... cell activation with marked delay or failure of target cell death mediated by lymphocytes. Furthermore, our finding that corruption of ...

Reciprocal regulation of human natural killer cells and macrophages ...

To assess NK cell cytotoxicity after coincubation with antigen-presenting cells (APCs), NK cells were first dissociated from APCs by incubation ...

Natural Killer cells | Institute of Experimental Immunology | UZH

... synapse mediating this NK activation by ... NK cell survival mediated through the regulatory synapse with human dendritic cells requires IL-15Ralpha.

Maintaining the Balance: Regulation of NK Cell Activity - MDPI

For example, activation with soluble ligands can occur through the NKG2D and NKp44 receptors. Tumors often try to evade NK cell-mediated control by shedding ...

NK cells are never alone: crosstalk and communication in tumour ...

In a mouse model injected with 4T1 breast cancer cells, neutrophils inhibited NK cell activity, thereby attenuating NK cell-mediated clearance ...