NLRP3 inflammasome and its activators
The NLRP3 inflammasome: molecular activation and regulation to ...
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, ...
The NLRP3 Inflammasome: An Overview of Mechanisms of ...
The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of ...
NLRP3 inflammasome activation and cell death - Nature
Because the NLRP3 inflammasome can be activated by multiple agonists, including PAMPs, such as viral RNAs, microbial toxins and bacterial ...
The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...
Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory ...
The NLRP3 inflammasome: contributions to inflammation-related ...
NLRP3 protein functions as a sensitive sensor, triggering downstream caspase-1 activation and releasing the cytokine IL-1β in response to ...
The NLRP3 inflammasome: activation and regulation - Cell Press
NLRP3 inflammasome is a cytoplasmic supramolecular complex that is activated in response to cellular perturbations triggered by infection and sterile injury.
Fantastic voyage: The journey of NLRP3 inflammasome activation
Abstract. NLRP3 inflammasome, an intracellular multiprotein complex, can be activated by a range of pathogenic microbes or endogenous hazardous chemicals. Its ...
Mechanism and Regulation of NLRP3 Inflammasome Activation
The NLRP3 inflammasome is an essential mediator of host immune responses through the activation of caspase-1 and interleukin 1 beta (IL-1β)/IL-18.
NLRP3 Inflammasome Activation - Promega Corporation
The NLRP3 inflammasome detects stress signals, like extracellular ATP released by damaged cells. These signals activate the inflammasome and recruit caspase-1 ...
The mechanism of NLRP3 inflammasome activation and its ...
The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.
Mechanism of NLRP3 inflammasome activation and its role in ...
This review aimed to clarify the structure and activating mechanism of NLRP3 inflammasome and its key role in the pathogenesis of AD
NLRP3 inflammasome and its inhibitors: a review - Frontiers
The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto- ...
The NLRP3 inflammasome: an emerging therapeutic target for ...
The activation procedure of NLRP3 inflammasome usually involves two phases (Fig. 1). The first phase is the priming phase, mediated primarily by ...
Mechanism of NLRP3 inflammasome activation - Sutterwala - 2014
The initial inflammasome priming step upstream of activation affects NLRP3 at the transcriptional level and also serves to trigger ...
New Insights on NLRP3 Inflammasome: Mechanisms of Activation ...
Among various inflammasomes, Nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) is the ...
Structural Mechanisms of NLRP3 Inflammasome Assembly and ...
... the inflammasome. We further implicate structure-derived mechanisms for the assembly and activation of the NLRP3 inflammasome.
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure ...
NLRP3 inflammasome is a multiprotein complex that combines sensing, regulation, and effector functions to regulate inflammation in health and disease.
The NLRP3 inflammasome: Mechanisms of activation, regulation ...
The NLRP3 inflammasome is activated by a variety of stimuli, and several molecular and cellular events, such as ion influx, mitochondrial dysfunction, reactive ...
The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver
This NLRP3 complex has been shown to be involved in multiple diseases including Alzheimer's disease, atherosclerosis, cryopyrin- associated periodic syndrome ( ...
NLRP3 Inflammasome Activation Model - Charles River Laboratories
Inflammasomes are defined as cytosolic multi-protein complexes that mediate activation of caspase-1 leading to the maturation and secretion of IL-1β and IL-18 ...