Natural Human IgE Monoclonal Antibody Defines a Unique Epitope ...

We report the first X-ray crystal structure of an allergen in complex with a human IgE mAb that has the natural pairing of heavy and light chains.

Unique Epitope for a Natural Human IgE Monoclonal Antibody on ...

IgE mAb 2F10 bound a unique site, non-overlapping with known murine IgG mAb epitopes. Heavy chain residues contribute to 72% of the allergen-antibody interface ...

Natural Human IgE Monoclonal Antibody Defines a Unique Epitope on Der p 2 There is limited knowledge of the epitopes associated with the ...

Mapping human monoclonal IgE epitopes on the major dust mite ...

Information about the epitopes recognized by IgE would be useful for designing new molecules for immunotherapy. However, very little is known about IgE antibody ...

Natural Human IgE Monoclonal Antibody Defines a Unique Epitope ...

Request PDF | Natural Human IgE Monoclonal Antibody Defines a Unique Epitope on Der p 2 | Rationale: There is limited knowledge of the epitopes associated ...

Human Monoclonal IgE Antibodies—a Major Milestone in Allergy

The molecular insights that IgE epitopes provide will allow for structure-based design approaches to the development of novel diagnostics, ...

Natural Human IgE Monoclonal Antibody Defines a Unique Epitope ...

Request PDF | On Feb 1, 2021, Anna Pomes and others published Natural Human IgE Monoclonal Antibody Defines a Unique Epitope on Der p 2 | Find, ...

Monoclonal antibodies against human IgE. identification of an ...

Monoclonal antibodies against human IgE. identification of an epitope sharing properties with the high-affinity receptor binding site ; Jaime Moscoso del Prado

Unique allergen-specific human IgE monoclonal antibodies derived ...

The novelty of the hIgE mAb is that they are derived from symptomatic allergic patients and represent part of the human IgE repertoire of these ...

The Potential of Human Monoclonal IgE Antibodies to Establish ...

Because human IgE mAb recognize biologically relevant epitopes, they present a novel opportunity to determine the potencies of allergenic ...

Monoclonal antibodies to three distinct epitopes on human IgE

The antibodies showed high avidities for soluble IgE (0.7 × 109 to 3.3 × 109 M−1). These MAb defined three distinct epitopes on IgE. A mixture of these ...

Human IgE monoclonal antibody recognition of mite allergen Der p ...

Early studies identified linear or continuous epitopes, by testing IgE antibody binding to linear peptides or recombinant allergen fragments and performing ...

A unique human IgE‐binding epitope on the Bermuda grass pollen ...

It appears that the epitope recognized by the lambda-type MoAbs is a human IgE-binding antigenic determinant. Further physicochemical analyses showed that this ...

Biological activity of human IgE monoclonal antibodies targeting Der ...

Background: Human Immunoglobulin E monoclonal antibodies (hIgE mAb) are unique tools for investigating IgE responses. Here, the biological activity of hIgE mAb, ...

Mapping Human Monoclonal IgE Epitopes on the Major Dust Mite ...

However, direct knowledge of the human IgE (hIgE) epitopes is limited because of the very low frequency of IgE-producing B cells in blood. A new hybridoma ...

Unique Epitope for a Natural Human IgE Monoclonal Antibody on ...

Journal of Allergy and Clinical Immunology ( IF 11.4 ) Submission Guide > Pub Date: 2022-02-01. DOI: 10.1016/j.jaci.2021.12.715

The mechanistic and functional profile of the therapeutic anti-IgE ...

A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with the ...

A Comparison of Natural and Therapeutic Anti-IgE Antibodies - MDPI

Omalizumab is currently the only licensed monoclonal antibody that selectively binds to IgE. Omalizumab binds to free IgE, preventing it from interacting with ...

Past, present, and future of anti‐IgE biologics - Wiley Online Library

The primary mode-of-action of this humanized monoclonal anti-IgE antibody of IgG1 subclass is the neutralization of free IgE. It binds with ...

IgE-neutralizing UB-221 mAb, distinct from omalizumab and ... - JCI

RBL SX-38 is a rat basophilic leukemia cell line expressing the α, β, and γ chains of human FcεRI that serves as a sensitive model for exploring ...