Natural killer cell cytotoxicity and its regulation by inhibitory receptors

Natural killer (NK) cells express an array of germ-line encoded receptors that are capable of triggering cytotoxicity. NK cells tend to express many members ...

Receptors for NK cell cytotoxicity. Natural killer cells express many receptors that can activate their cytotoxic and secretory functions. These receptors ...

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

Natural killer (NK) cells utilize an array of germ-line encoded activating and inhibitory receptors to sense their surroundings.

Inhibitory Receptors and Checkpoints in Human NK Cells ... - Frontiers

In this contribution, we will delineate some of the main inhibitory receptors expressed by human NK cells. Remarkably, Killer Ig-like Receptors (KIR), ...

triggering and inhibitory human NK receptors | The EMBO Journal

Natural killer (NK) cells represent a highly specialized lymphoid population characterized by a potent cytolytic activity against tumor or virally infected ...

Activating and Inhibitory Natural Killer Cell Receptors - R&D Systems

Activating NK cell receptors include members of the human Killer Immunoglobulin-like Receptor (KIR) family or the mouse Ly49 family, CD94-NKG2C/E/H ...

Functions of natural killer cells | Nature Immunology

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections.

The Molecular Mechanism of Natural Killer Cells Function and Its ...

The interaction of NK cell inhibitory receptors natural-killer group 2 ... receptor involved in natural cytotoxicity mediated by human natural killer cells.

Natural Killer Cell Receptor - an overview | ScienceDirect Topics

... killer-cell immunoglobulin-like receptors (KIR). Despite the presence of killer cell receptors and cytotoxic granules, uterine NK cells are poorly cytotoxic.

Regulation of natural killer cell activity by glucocorticoids, serotonin ...

In this review, we will focus on how the nervous system influences the activity of the immune system using natural killer (NK) cells as an example.

Inhibitory Receptors and Immune Checkpoints Regulating Natural ...

In this review we focused on cytotoxic lymphocytes Natural Killer (NK) cells, which are known to be well equipped in the fight against cancer. We explored the ...

Natural Killer Cell Cytotoxicity And Its Regulation By Inhibitory ...

Natural Killer (NK) cells are potent immune effector cells that play a major role in innate defences against viruses and tumors (1). Through an ...

Natural killer cell receptors: new biology and insights into the graft ...

Abstract. Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades. However, to date only modest clinical.

Activating and inhibitory receptors of natural killer cells - Pegram

These will be highlighted and discussed in this review. Natural killer (NK) cells are lymphocytes that are part of the innate immune system.

Regulation through inhibitory receptors: lessons from natural killer ...

Human NK cells express killer cell inhibitory recep- tors (KIRs) that are type I transmembrane proteins. (i.e. their N-terminal end is lumenal) with immuno-.

NK Cell Activation Receptors and Ligands Pathway - R&D Systems

Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. Click on one of the links shown in the Explore Pathways box below ...

Regulation through inhibitory receptors: Lessons from natural killer ...

Natural killer (NK) cells employ an unconventional mode of recognition: they kill target cells that lack ligands for inhibitory NK cell receptors.

KEGG PATHWAY: map04650

Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and ...

T cell regulation of natural killer cells - Rockefeller University Press

In light of their role in the immune response against tumors and viruses, natural killer (NK) cells represent a promising target for ...

Activating and Inhibitory NK Cell Receptors - SpringerLink

Four distinct types of NK cell receptors for MHC class I that inhibit NK cell-mediated cytotoxicity have been identified.