Navigating High|Risk and Ultrahigh|Risk Multiple Myeloma

Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma

We defined ultrahigh-risk (uHR)MM as MM leading to death within 24-36 months of diagnosis and HRMM as MM leading to death within 36-60 months.

Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma - PubMed

Despite significant improvement in the outcomes of patients with newly diagnosed multiple myeloma (NDMM) with novel therapies, there is still an underserved ...

Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma

Abstract. Despite significant improvement in the outcomes of patients with newly diagnosed multiple myeloma (NDMM) with novel therapies, there is still an ...

Reaching Consensus on Defining, Treating High-Risk Myeloma

A new consensus definition for high-risk myeloma patients and promising results from trials dedicated to their care may offer a "paradigm ...

IMS 2024: News for High-Risk Multiple Myeloma - HealthTree

The definition and treatment of high-risk multiple myeloma are evolving as researchers gain a deeper understanding of the disease's genetics and ...

Navigating High-Risk Disease in Multiple Myeloma - Cancer Network

Experts dive into the complexities of defining and treating high-risk Multiple Myeloma (MM) and discuss the role of ASCT in newly diagnosed ...

High-Risk Multiple Myeloma: Definition & Treatment - HealthTree

Diagnosed With High-Risk Myeloma, What Now? ... Multiple myeloma is a blood cancer that develops in plasma cells, a type of white blood cell found ...

Definers and drivers of functional high-risk multiple myeloma

We define this entity as functional high-risk MM (FHRMM), encompassing relapse within 18 months of treatment initiation and/or within 12 months of frontline ...

Managing Ultra High-Risk Multiple Myeloma - Patient Power

Doctor Shares Treatment Options for Ultra High-Risk Myeloma. Managing high-risk and ultra high-risk multiple myeloma and cases that respond ...

What does it mean to have functional high-risk multiple myeloma?

Myeloma expert Dr. Brian G.M. Durie discusses what it means when a patient is functionally high risk and what new therapies may benefit these ...

Ultra High-Risk Multiple Myeloma Patients with Multi-Hit Tumours ...

Ultra high-risk multiple myeloma patients with multi-hit tumours and SKY92 high risk signature are at increased risk of early relapse even when treated with ...

Answers to FAQs from our 8/25/23 webinar on High-Risk Multiple ...

A patient cannot convert from having high-risk to standard-risk MM following treatment. ... However, when the myeloma becomes active again and the ...

Treatment of multiple myeloma with high-risk cytogenetics

The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic ...

Perspectives on the Risk-Stratified Treatment of Multiple Myeloma

In this article, we discuss data supporting multiple myeloma risk stratification, current therapeutic approaches for HR disease, and set out the ...

Risk Factors for Multiple Myeloma | American Cancer Society

Age. The risk of developing multiple myeloma goes up as people get older. · Sex. Men are slightly more likely to develop multiple myeloma than ...

Gene Expression Profiling in Multiple Myeloma - Frontiers

In literature, these patients are referred to as high-risk patients. The definition of high risk has evolved over time and there are still many variations on ...

Experts' consensus on the definition and management of high risk ...

High risk multiple myeloma (HRMM) at diagnosis is currently recognized according to the Revised International Staging System (R-ISS) which was ...

Multiple myeloma: 2024 update on diagnosis, risk-stratification, and ...

Risk stratification: The presence of del(17p), t(4;14), t(14;16), t(14;20), gain 1q, del 1p, or p53 mutation is considered high-risk multiple myeloma. Presence ...

Multiple Myeloma Screening | Winship Cancer Institute of Emory ...

Screening for High-Risk Patients · Monoclonal gammopathy of undetermined significance (MGUS) — About 1% of people with MGUS will go on to develop one of these ...

Analytical Validation of SKY92 for the Identification of High-Risk ...

Multiple myeloma (MM) is an incurable plasma cell cancer with a large variability in survival. Patients with MM classified as high risk by ...