Neuronal|Astrocyte Metabolic Interactions

Neuronal-Astrocyte Metabolic Interactions - PubMed Central

Astrocytoma cells appear to retain basic metabolic mechanisms of astrocytes, for example, they show a high glycolytic rate, lactate extrusion, ability to ...

Neuron–astrocyte metabolic coupling facilitates spinal plasticity and ...

We find that spinal astrocytes and neurons metabolically interact and that strong, long-lasting pain stimuli have pronounced effects on dynamic ...

Astrocyte metabolism and signaling pathways in the CNS - Frontiers

Neurotransmitters released by neurons during enhanced synaptic activity may interact with astrocytes, stimulating the production of lactate and ketones for ...

Astrocyte-neuron metabolic cooperation shapes brain activity

Astrocytes generate abundant mitochondrial reactive oxygen species and shuttle to neurons glycolytically derived metabolites, such as L-lactate and L-serine.

Neuron-Astrocyte Metabolic Coupling Protects against Activity ...

An important area in neuron-astrocyte interaction relates to the metabolism of fatty acids (FAs). FAs are components of phospholipids in ...

Metabolic compartmentalization between astroglia and neurons in ...

Astroglia or astrocytes, the most abundant cells in the brain, are interposed between neuronal synapses and microvasculature in the brain ...

Functional metabolic interactions of human neuron-astrocyte 3D in ...

Here, we demonstrate the establishment of neuronal and astrocytic metabolic signatures and shuttles in a human 3D neural cell model, namely the glutamine- ...

Neuronal-astrocyte metabolic interactions - APA PsycNet

Brain function depends on complex metabolic interactions among only a few different cell types, with astrocytes providing critical support for neurons.

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic ...

This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration

Metabolic interaction between astrocytes and neurons is disrupted in AD and PD. Both diseases present cerebral hypoperfusion with associated degradation of BBB ...

1: Neuron and astrocyte metabolism - Medicine LibreTexts

This compartmentalized, coupled metabolism between neurons and astrocytes is essential for ATP production, neuronal excitability, and adaptations to stress.

Neuron-Astrocyte Interactions: Partnership for Normal Function and ...

Interactions between neurons and astrocytes are critical for signaling, energy metabolism, extracellular ion homeostasis, volume regulation, and ...

Metabolic Interactions between Neurons and Astrocytes - SpringerLink

Metabolic interactions between neurons and glial cells can occur in at least two different ways, 1) transfer of a metabolite from a cell type, competent in ...

Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases

The metabolic interactions between astrocytes and neurons, astrocytes and microglia were also detailed discussed. Finally, we classified ...

Metabolic switch in the aging astrocyte supported via integrative ...

Dysregulated central-energy metabolism is a hallmark of brain aging. Supplying enough energy for neurotransmission relies on the neuron-astrocyte metabolic ...

Response to 'Comment on Recent Modeling Studies of Astrocyte ...

Let us begin this commentary by summarizing two contrasting perspectives on the modeling of cerebral energy metabolism and neuronal-glial interactions. One is ...

Astrocytes and Astrocyte–Neuron Interactions - Oxford Academic

Astrocytes are primarily affected in metabolic, genetic, and immune astrocytopathies and have a major role in the pathophysiology of epilepsy and in vascular, ...

Astrocyte Metabolism and Astrocyte-Neuron Interaction - SpringerLink

L. Pellerin, and P. Magistretti, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, ...

Ketogenic diet and astrocyte/neuron metabolic interactions | OCL

Though anticonvulsant activity of ketogenic diet has been well documented by a large number of experimental and clinical studies, underlying mechanisms still ...

Neuron–astrocyte interactions in the regulation of brain energy ...

This improved understanding of neuron–astrocyte metabolic interactions offers the potential for developing novel therapeutic strategies for many ...