Neuronal Cell Death Mechanisms in Major Neurodegenerative ...

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, ...

In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common ...

Molecular mechanisms of cell death in neurological diseases - Nature

In PD, the predominant mechanism of neuronal death is thought to be via the intrinsic apoptosis pathway in dopaminergic neurons. Inherited forms ...

Neuronal Cell Death Mechanisms in Major Neurodegenerative ...

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death ...

Neuronal cell death and neurodegenerative disease | BMG LABTECH

Some of the main routes to destruction for neuronal cells include apoptosis, necrosis and autophagy. ... Each has its own distinctive features, ...

Neuronal cell death mechanisms in Alzheimer's disease: An insight

Aberrant activation of this pathway results in cell death by various mechanisms including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy- ...

Neuronal Cell Death Mechanisms in Major Neurodegenerative ...

However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain ...

Neuronal cell death in neurodegenerative diseases: recurring ...

This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, ...

Neuronal Cell Death | Physiological Reviews

We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic ...

Neuronal Cell Death - an overview | ScienceDirect Topics

There are three main mechanisms of neuronal cell death which may act separately or cooperatively to cause neurodegeneration. ... For a more in depth discussion of ...

The neuroprotective effects of targeting key factors of neuronal cell ...

Thus, endoplasmic reticulum (ER) stress, oxidative stress, and neuroinflammation are the major pathological factors of neuronal cell death. Even though the ...

Cell Death and Neurodegenerative Diseases: Mechanisms ... - MDPI

A neurodegenerative disease is a pathological condition affecting neurons, condemning them to death. The term covers a heterogeneous range ...

Neuronal cell death in neurodegenerative diseases: recurring ...

This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death.

Diversity in the Mechanisms of Neuronal Cell Death - ScienceDirect

The best-understood mechanism of neuronal cell death is apoptosis, which is regulated by an evolutionarily conserved cellular pathway.

Mitochondrial and Cell Death Mechanisms in Neurodegenerative ...

Some forms of AD, PD, and ALS are inherited, and genes causing these diseases have been identified. Nevertheless, the mechanisms of the neuronal cell death are ...

Regulated cell death: discovery, features and implications for ...

ALS is a progressive neurodegenerative disease for which the pathophysiological mechanisms of motor neuron loss are not precisely clarified [4].

Necroptosis in neurodegenerative diseases: a potential therapeutic ...

... major driver of neuron cell death in neurodegenerative diseases ... Very little is known about the cellular death mechanisms leading to neuronal ...

The enigma of cell death in neurodegenerative disorders

Progressive cell loss in specific neuronal populations is the pathological hallmark of neurodegenerative diseases, but its mechanisms remain unresolved.

Cell Cycle Deficits in Neurodegenerative Disorders

Upon NGF withdrawal, neuronal cells exhibit programmed cell death features associated with global decline in RNA and protein synthesis with concomitant decrease ...

Mechanisms of Neurodegenerative Disorders: Part 2: Control of Cell ...

Apoptotic pathways. In neurons, the main pathway regulating apoptosis seems to be mediated by tyrosine kinases. In this pathway, growth factors ...