Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are ...

Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis ...

Mitochondrial dysfunction in ALS patients has been known for more than 50 years, and the involvement of mitochondria in the pathophysiology of this disease is ...

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid ...

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective death of upper and lower motor neurons which ...

(PDF) Neuronal mitochondrial dysfunction in sporadic amyotrophic ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are ...

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal ...

The role of mitochondria in amyotrophic lateral sclerosis

Motor neuron disease (MND) describes a group of neurological disorders characterised by the selective loss of motor neurons. Amyotrophic lateral ...

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics - Frontiers

Amyotrophic lateral sclerosis (ALS) is a progressive and devastating multifactorial neurodegenerative disorder. Although the pathogenesis of ALS is still ...

Mitochondrial Alterations in the Spinal Cord of Patients With ...

Accumulating evidence shows that mitochondrial damage is involved in motor neuron degeneration in sporadic amyotrophic lateral sclerosis (ALS) (1-3), familial ...

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral ...

Thus, mitochondrial dysfunction creates a vicious cycle of neuronal damage, genetic mutation, and metabolic stress, which may lead to apoptosis, which can lead ...

Mitochondrial dysfunction in ALS - ScienceDirect.com

In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.

Mitochondrial dysregulation occurs early in ALS motor cortex with ...

... neurons (UMNs) with TDP-43 pathology, a pathology that is predominantly present in both familial and sporadic cases of amyotrophic lateral ...

Ultrastructural Mitochondrial Abnormalities in Patients With Sporadic ...

Higgins et al described vacuolated mitochondria in the early phases of motor neuron degeneration in transgenic mice with familial amyotrophic lateral sclerosis ...

Discrete mitochondrial aberrations in the spinal cord of sporadic ...

Mitochondrial abnormalities observed in amyotrophic lateral sclerosis (ALS) spinal cords might be closely related to motor neuron degeneration.

Mitochondrial dysfunction in familial amyotrophic lateral sclerosis

A growing body of evidence suggests that mitochondrial dysfunctions play a crucial role in the pathogenesis of various neurodegenerative ...

Mitochondrial Alterations in the Spinal Cord of Patients With ...

mitochondria in sporadic amyotrophic lateral sclerosis (ALS). We ... familial ALS-linked SOD1 mutation causes motor neuron disease characterized ...

SOD1 misplacing and mitochondrial dysfunction in amyotrophic ...

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease presenting as sporadic (sALS) or familial (fALS) forms. Even if the list of the genes ...

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral ...

Collectively, our data show that loss of mitochondrial function is a key mediator of axonal dysfunction in C9orf72-ALS, and that boosting MN ...

Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis ...

Amyotrophic lateral sclerosis is a severe neurodegenerative disease whose exact cause is still unclear. Currently, research attention is turning to the ...

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

Mitochondrial dysfunction has been consistently reported in ALS patients and ALS in vitro and in vivo experimental models, although the ...

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential ...