New genomic predictors of relapse in childhood B|cell acute ...

New genomic predictors of relapse in childhood B-cell acute ...

This study is one of the first to systematically examine genetic factors on a large scale that influence relapse risk in SR B-ALL.

Scientists identify genes linked to relapse in the most common form ...

Researchers identified genetic predictors of relapse in standard risk B-cell acute lymphoblastic leukemia highlighting the role of genetic testing in tailoring ...

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia

Genetic subtype, patterns of aneuploidy, and secondary genomic alterations determine risk of relapse in childhood ALL.

Integrated genomic analysis of relapsed childhood acute ...

CNA analysis discovered CNAs that were shared at diagnosis and relapse and others that were new lesions acquired at relapse. DNA methylation analysis found ...

Scientists identify genes linked to relapse in the most common form ...

Scientists have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic ...

Genetic variants influencing SR B-ALL relapse risk identified

Genome and transcriptome sequencing revealed that subtypes such as TCF3/4::HLF were associated with an increased risk of relapse.

Upfront Treatment Influences the Composition of Genetic Alterations ...

Genomic alterations in relapsed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) may provide insight into the role of specific genomic events in relapse ...

Researchers Identified Genomic Aberrations Linked With Relapse in ...

Comprehensive genomic analysis is essential for successful risk stratification among pediatric patients with standard-risk B cell acute ...

Mutational mechanisms in multiply relapsed pediatric acute ... - Nature

We then investigated the timing and continuity of mutational processes in the multiple sequential samples of each patient (Fig. 3A, B). Similar ...

Identification of Early Recurrence Factors in Childhood ... - Frontiers

Acute lymphoblastic leukemia is the most common cancer in children, and includes both B-cell and T-cell lineages. B-ALL accounts for about 85% of pediatric ALL ...

New genomic predictors of relapse in childhood B-cell acute ... - MSN

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered · Identifying genetic variations that modulate risk · Authors and ...

Advances in next-generation sequencing for relapsed pediatric ...

Mutations observed in different gene regulation pathways showed different frequencies of relapse-enriched genes between B- and T-ALL, implying ...

Integrative genomic analysis of childhood acute lymphoblastic ...

Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has ...

New and emerging prognostic and predictive genetic biomarkers in ...

High-risk genetic biomarkers are four times more prevalent in adults compared to children. The application of genomic technologies to cases ...

Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®) - NCI

[156] The landmark analysis demonstrated an almost threefold reduction in relapse rate and an improvement in the 2-year EFS rate (from 74.4% to ...

Refining risk prediction in pediatric acute lymphoblastic leukemia ...

Upfront treatment is primarily based on combination chemotherapy. Prognostic factors have been used to estimate the risk of relapse and to ...

Clonal dynamics in pediatric B‐cell precursor acute lymphoblastic ...

Comprehensive genomic characterization of diagnosis–relapse pairs shows that very early relapses in BCP-ALL frequently arise from minor ...

Gene expression classifiers for relapse-free survival and minimal ...

To determine whether gene expression profiling could improve outcome prediction in children with acute lymphoblastic leukemia (ALL) at high risk for relapse ...

Nucleotide excision repair is a predictor of early relapse in pediatric ...

In the late relapsing subgroup of the Staal dataset, 16/20 NER genes were upregulated at relapse compared with diagnosis (Fig. 2d). Upregulation ...

Redefining ALL classification: toward detecting high-risk ALL and ...

Moreover, sequential sequencing studies at diagnosis, remission, and relapse have provided important insights into the relationship among genetic variants, ...