New pathway linking neuron selectivity to cognitive disorders ...

The research, published October 2 in Nature, reveals how a molecule, the calcium permeable (CP)-AMPA receptor, suppresses a specific neuron's ability to pay ...

New pathway linking neuron selectivity to cognitive disorders uncovered ... “Making neuron inhibition less selective makes our neural circuits more ...

The kynurenine pathway as a therapeutic target in cognitive and ...

The neural complexity of cognitive function makes it exceptionally difficult to identify specific neurochemical substrates, especially those that could provide ...

New pathway linking neuron selectivity to cognitive disorders ... - MSN

Neuroscientists from Johns Hopkins Medicine say they have determined how a brain cell surface molecule shapes the way certain neurons behave.

Brain Cell News, Research

New pathway linking neuron selectivity to cognitive disorders uncovered. Neuroscientists from Johns Hopkins Medicine say they have determined how a brain cell ...

Neuroligins and Neurexins Link Synaptic Function to Cognitive ...

In humans, alterations in neurexin or neuroligin genes are implicated in autism and other cognitive diseases, connecting synaptic cell adhesion to cognition and ...

A New Field of Neuroscience Aims to Map Connections in the Brain

This technique allows us to identify excitatory and inhibitory neurons, as well as the synapses, or small gaps where neurons connect to each ...

Neurotrophin-targeted therapeutics: A gateway to cognition and more?

The neurotrophins BDNF and NGF have been studied extensively and have important roles in neuronal survival, differentiation, neurogenesis, and synaptic ...

New articles: Neuron - Cell Press

Kim et al. developed a human assembloid to investigate the effects of calcium channel function on the thalamocortical pathway. The M1531V CACNA1G variant ...

G protein-coupled receptors in neurodegenerative diseases ... - Nature

Brain adrenergic receptors on neurons and glia are activated by the monoamine neurotransmitter norepinephrine (produced primarily in the locus ...

Somatostatin: Linking Cognition and Alzheimer Disease to ...

In those with a confirmed diagnosis of AD, the relative abundance of the vulnerable SRIF neurons was significantly higher in those without cognitive impairment ...

Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and ...

TrkA is also increasingly lost in mild cognitive impairment and AD (Fahnestock and Shekari, 2019). Studies modeling aging with embryonic rat basal forebrain ...

The Amyloid-β Pathway in Alzheimer's Disease | Molecular Psychiatry

The impact of the APOE genotype on the risk of AD cognitive-functional decline is likely to be Aβ-mediated [56]. The effect of APOE ε4 on Aβ ...

The hippocampal–prefrontal pathway: The weak link in psychiatric ...

Considering that these disorders involve varying degrees of cognitive impairment and emotional dysregulation, dysfunction in the H-PFC pathway might therefore ...

The neuropathological diagnosis of Alzheimer's disease

Neuronal loss parallels the distribution of neurofibrillary tangles in AD, and it is a better correlate of cognitive deficits than the tau ...

Restoring neuronal chloride extrusion reverses cognitive decline ...

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However ...

New clues for the role of cerebellum in schizophrenia and ... - Frontiers

The loss of microconnectivity can cause aberrant myelination, impaired connectivity, and cognitive deficits (Valdés-Tovar et al., 2022; Wu et al., 2022). The ...

Vascular Contributions to Cognitive Impairment and Dementia | Stroke

The neuropathology of cognitive impairment in later life is often a mixture of Alzheimer disease and microvascular brain damage, which may ...

Exploring the Role of Neuroplasticity in Development, Aging, and ...

Of note, new neurons also need to migrate to their appropriate locations within the brain. This process involves the support of radial glial cells and Cajal– ...

Amplified selectivity in cognitive processing implements the neural ...

Mather and colleagues' article joins the growing body of work suggesting that norepinephrine, through its brainwide effect on neural gain, selectively enhances ...